GLI1 is a transcriptional effector at the terminal end of the Hedgehog signaling (Hh) pathway
and is tightly regulated during embryonic development and tissue patterning/differentiation …

Background: Despite all the advances achieved in the field of tumor-biology research, in
most cases conventional therapies including chemotherapy are still the leading choices. The …

Colorectal cancer (CRC) is one of the most common gastrointestinal cancers worldwide. It is
a complicated and often fatal cancer, and is related to a high disease-related mortality …

Tumors are phenotypically heterogeneous and include a small sub-population of cancer
cells (2–5% of the tumor mass) with stem-cell like properties. The cancer stem cell …

There is accumulating evidence that breast cancer may arise from a small subpopulation of
transformed mammary stem/progenitor cells, termed breast cancer-initiating cells (BCICs) …

The protein kinase R (PKR, also called EIF2AK2) is an interferon-inducible double-stranded
RNA protein kinase with multiple effects on cells that plays an active part in the cellular …

Accumulating evidence shows that colorectal cancer stem cells (CRSCs) are largely
responsible for the metastasis and relapse of colorectal cancer (CRC) after therapy. Hence …

Maslinic acid (MA) is a natural pentacyclic triterpenoid with inherent antitumor activity which
has a very low solubility in water. MA solid lipid nanoparticles (SLNs) were prepared using …

There is a global need to discover effective anti-cancerous compounds from natural sources.
Cultivated wheat cells can be a valuable source of non-toxic or low toxic plant-derived …

Colorectal cancer is a major health problem worldwide. Aberrant activation of the Wingless-
type mouse mammary tumor virus integration site family (Wnt)/β-catenin signaling pathway …