Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

An increasing body of evidence has implicated the central muscarinic system as contributing
to a number of symptoms of schizophrenia and serving as a potential target for …

The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

The muscarinic cholinergic system constitutes an important part of the neuronal circuitry that
modulates normal cognition. Muscarinic receptor antagonists are well known to produce or …

Sensorimotor gating, or the ability of a sensory event to suppress a motor response, can be
measured operationally via prepulse inhibition (PPI) of the startle response. PPI is deficient …

Current antipsychotic drugs provide symptomatic relief for positive symptoms of
schizophrenia, but do not offer symptom management for negative and cognitive symptoms …

Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …

Because the five muscarinic acetylcholine receptor subtypes have overlapping distributions
in many CNS tissues, and because ligands with a high degree of selectivity for a given …

Modelling of complex psychiatric disorders, eg, depression and schizophrenia, in animals is
a major challenge, since they are characterized by certain disturbances in functions that are …

Background In the central nervous system (CNS), the muscarinic system plays key roles in
learning and memory, as well as in the regulation of many sensory, motor, and autonomic …