[HTML][HTML] SARS-CoV-2 infections in children: Understanding diverse outcomes

P Brodin - Immunity, 2022 - cell.com
SARS-CoV-2 infections mostly lead to mild or even asymptomatic infections in children, but
the reasons for this are not fully understood. More efficient local tissue responses, better …

The microbe, the infection enigma, and the host

JL Casanova, L Abel - Annual Review of Microbiology, 2024 - annualreviews.org
Human infectious diseases are unique in that the discovery of their environmental trigger,
the microbe, was sufficient to drive the development of extraordinarily effective principles …

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

K Sacco, R Castagnoli, S Vakkilainen, C Liu… - Nature medicine, 2022 - nature.com
Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

D Lee, J Le Pen, A Yatim, B Dong, Y Aquino, M Ogishi… - Science, 2022 - science.org
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …

Multisystem inflammatory syndrome in children and long COVID: the SARS-CoV-2 viral superantigen hypothesis

M Noval Rivas, RA Porritt, MH Cheng, I Bahar… - Frontiers in …, 2022 - frontiersin.org
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory
disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C …

Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: a national post-authorization pharmacovigilance study

N Ouldali, H Bagheri, F Salvo, D Antona… - The Lancet Regional …, 2022 - thelancet.com
Background Multisystem inflammatory syndrome in children (MIS-C) is the most severe
clinical entity associated with pediatric SARS-CoV-2 infection with a putative role of the …

Molecular mimicry in multisystem inflammatory syndrome in children

A Bodansky, RC Mettelman, JJ Sabatino Jr… - Nature, 2024 - nature.com
Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela
of SARS-CoV-2 infection,, yet the pathophysiological mechanism connecting the infection to …

Multisystem inflammatory syndrome and autoimmune diseases following COVID-19: molecular mechanisms and therapeutic opportunities

P Hosseini, MS Fallahi, G Erabi, M Pakdin… - Frontiers in molecular …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2), has led to huge concern worldwide. Some SARS-CoV-2 …

SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19

K Rybkina, JN Bell, MC Bradley, T Wohlbold… - Journal of Experimental …, 2023 - rupress.org
SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare
cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) …

The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2–associated multisystem inflammatory syndrome in children

M Benamar, Q Chen, J Chou, AM Julé… - The Journal of …, 2023 - Am Soc Clin Investig
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients
following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas …