Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

T Sakuragi, S Nagata - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

[HTML][HTML] Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

MM McDonald, WH Khoo, PY Ng, Y Xiao, J Zamerli… - Cell, 2021 - cell.com
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

Novel insights into macrophage diversity in rheumatoid arthritis synovium

MA Boutet, G Courties, A Nerviani, B Le Goff… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and
causing progressive damage and disability. Macrophages are of critical importance in the …

Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration

W Qiao, H Xie, J Fang, J Shen, W Li, D Shen, J Wu… - Biomaterials, 2021 - Elsevier
Macrophage has been gradually recognized as a central regulator in tissue regeneration,
and the study of how macrophage mediates biomaterials-induced bone regeneration …

Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration

R Toita, JH Kang, A Tsuchiya - Acta Biomaterialia, 2022 - Elsevier
An appropriate immune microenvironment, governed by macrophages, is essential for rapid
tissue regeneration after biomaterial implantation. The macrophage phenotypes, M1 …

Influence of the TGF-β superfamily on osteoclasts/osteoblasts balance in physiological and pathological bone conditions

J Jann, S Gascon, S Roux, N Faucheux - International journal of …, 2020 - mdpi.com
The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Multinucleated giant cells: current insights in phenotype, biological activities, and mechanism of formation

K Ahmadzadeh, M Vanoppen, CD Rose… - Frontiers in cell and …, 2022 - frontiersin.org
Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Flagging fusion: Phosphatidylserine signaling in cell–cell fusion

JM Whitlock, LV Chernomordik - Journal of Biological Chemistry, 2021 - ASBMB
Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …

[PDF][PDF] Pharmacological agents and natural compounds: available treatments for osteoporosis.

M Martiniakova, M Babikova, R Omelka - Journal of Physiology & …, 2020 - jpp.krakow.pl
Osteoporosis, a systemic skeletal disease characterized by a decrease in bone mass and
deterioration of bone structure leading to an increased risk of fragility fractures, represents …