Public health and health service interventions are typically complex: they are multifaceted,
with impacts at multiple levels and on multiple stakeholders. Systematic reviews evaluating …

Using a novel technique known as network meta-analysis, we synthesized evidence from
492 studies (87,418 participants) to investigate the effectiveness of procedures in changing …

Most diseases have more than two interventions or treatment methods, and the application
of network meta-analysis (NMA) studies to compare and evaluate the superiority of each …

Model‐based meta‐analysis (MBMA) is increasingly used in drug development to inform
decision‐making and future trial designs, through the use of complex dose and/or time …

Network meta‐analysis has evolved into a core method for evidence synthesis in health
care. In network meta‐analysis, 3 or more treatments for a given medical condition are …

Background Computerized cognitive training (CCT) is a broad category of drill-and-practice
interventions aims to maintain cognitive performance in older adults. Despite a supportive …

Background Synthesis of clinical effectiveness from multiple trials is a well-established
component of decision-making. Time-to-event outcomes are often synthesised using the …

Background: Although immune checkpoint inhibitors (ICIs) and targeted therapies have
been widely used as adjuvant treatment for resected melanoma, the optimal therapy …

Surrogate endpoints are very important in regulatory decision making in healthcare, in
particular if they can be measured early compared to the long‐term final clinical outcome …

Background Sparse relative effectiveness evidence is a frequent problem in Health
Technology Assessment (HTA). Where evidence directly pertaining to the decision problem …