The platelet lifeline to cancer: challenges and opportunities

M Haemmerle, RL Stone, DG Menter… - Cancer cell, 2018 - cell.com
Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …

Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled …

PM Rothwell, JF Price, FGR Fowkes, A Zanchetti… - The Lancet, 2012 - thelancet.com
Background Daily aspirin reduces the long-term risk of death due to cancer. However, the
short-term effect is less certain, especially in women, effects on cancer incidence are largely …

Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer: the CALGB/SWOG 80702 …

JA Meyerhardt, Q Shi, CS Fuchs, J Meyer… - Jama, 2021 - jamanetwork.com
Importance Aspirin and cyclooxygenase 2 (COX-2) inhibitors have been associated with a
reduced risk of colorectal polyps and cancer in observational and randomized studies. The …

Aspirin in the chemoprevention of colorectal neoplasia: an overview

AT Chan, N Arber, J Burn, WK Chia, P Elwood… - Cancer prevention …, 2012 - AACR
Considerable evidence supports the effectiveness of aspirin for chemoprevention of
colorectal cancer (CRC) in addition to its well-established benefits in the prevention of …

[HTML][HTML] Aspirin in the treatment of cancer: reductions in metastatic spread and in mortality: a systematic review and meta-analyses of published studies

PC Elwood, G Morgan, JE Pickering, J Galante… - PloS one, 2016 - journals.plos.org
Background Low-dose aspirin has been shown to reduce the incidence of cancer, but its
role in the treatment of cancer is uncertain. Objectives We conducted a systematic search of …

Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis

P Li, H Wu, H Zhang, Y Shi, J Xu, Y Ye, D Xia, J Yang… - Gut, 2015 - gut.bmj.com
Objective The objective of this meta-analysis was to systematically assess the survival
benefit of aspirin use before or after diagnosis for patients with colorectal cancer (CRC) …

Use of aspirin postdiagnosis improves survival for colon cancer patients

E Bastiaannet, K Sampieri, OM Dekkers… - British journal of …, 2012 - nature.com
Background: The preventive role of non-steroid anti-inflammatory drugs (NSAIDs) and
aspirin, in particular, on colorectal cancer is well established. More recently, it has been …

Aspirin for the prevention of colorectal cancer

X Garcia-Albeniz, AT Chan - Best practice & research Clinical …, 2011 - Elsevier
Over 600,000 people worldwide die of colorectal cancer (CRC) annually, highlighting the
importance of developing effective prevention strategies. Among proposed chemopreventive …

Aspirin and COX-2 inhibitor use in patients with stage III colon cancer

K Ng, JA Meyerhardt, AT Chan, K Sato… - Journal of the …, 2015 - academic.oup.com
We conducted a prospective, observational study of aspirin and COX-2 inhibitor use and
survival in stage III colon cancer patients enrolled in an adjuvant chemotherapy trial. Among …

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology

S Ogino, P Lochhead, E Giovannucci, JA Meyerhardt… - Oncogene, 2014 - nature.com
Regular use of aspirin reduces incidence and mortality of various cancers, including
colorectal cancer. Anticancer effect of aspirin represents one of the 'Provocative Questions' …