The mitochondrial permeability transition pore was originally described in the 1970's as a
Ca 2+ activated pore and has since been attributed to the pathogenesis of many diseases …

After an acute ischemic stroke (AIS), inflammatory processes are able to concomitantly
induce both beneficial and detrimental effects. In this narrative review, we updated evidence …

Background Successful reperfusion is the most effective strategy to reduce ischemic injury in
acute myocardial infarction (AMI). Ischemic injury, however, also triggers a secondary …

Stroke is the leading cause of disability in adults. Drug treatments that target stroke-induced
pathological mechanisms and promote recovery are desperately needed. In the brain, an …

Mitochondrial dysfunctions are among the main hallmarks of several brain diseases,
including ischemic stroke. An insufficient supply of oxygen and glucose in brain cells …

Oxidative stress and mitochondrial dysfunction are frequently implicated in the pathology of
secondary neuronal damage following cerebral ischemia/reperfusion. Recent evidence …

Myocardial conditioning is an endogenous cardioprotective phenomenon that profoundly
limits infarct size in experimental models. The current challenge is to translate this paradigm …

Introduction Clinically, significant stroke injury results from ischemia-reperfusion (IR), which
induces a deleterious biphasic opening of the blood-brain barrier (BBB). Tissue …

Reperfusion is the only existing strategy for patients with acute ischemic stroke, however it
causes further brain damage itself. A feasible therapy targeting reperfusion injury is remote …

Ischemic stroke is a devastating disease with complex pathophysiology. Much evidence
confirms that opening of the mitochondrial permeability transition pore (MPTP) is related with …