More than mortar: glia as architects of nervous system development and disease

I Lago-Baldaia, VM Fernandes… - Frontiers in Cell and …, 2020 - frontiersin.org
Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …

Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism

Y Wang, H Hu, X Liu, X Guo - Frontiers in Pharmacology, 2023 - frontiersin.org
Alzheimer's Disease (AD) is a global chronic disease in adults with beta-amyloid (Aβ)
deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although …

Andrographolide attenuates short-term spatial and recognition memory impairment and neuroinflammation induced by a streptozotocin rat model of Alzheimer's …

LC Souza, MK Andrade, EM Azevedo, DC Ramos… - Neurotoxicity …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder clinically manifested by a gradual
cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of …

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions

SAH Dass, K McCracken, I Pokhvisneva, LM Chen… - …, 2019 - thelancet.com
Background Activation of brain insulin receptors modulates reward sensitivity, inhibitory
control and memory. Variations in the functioning of this mechanism likely associate with …

Metabolic hormones mediate cognition

OR Ghosh-Swaby, AC Reichelt, PAS Sheppard… - Frontiers in …, 2022 - Elsevier
Recent biochemical and behavioural evidence indicates that metabolic hormones not only
regulate energy intake and nutrient content, but also modulate plasticity and cognition in the …

siRNA Mediated GSK3β Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimer's Disease Pathology: Evidence from In Vitro and In Vivo Studies

S Gupta, V Singh, S Ganesh, NK Singhal… - ACS Applied Materials …, 2021 - ACS Publications
Sporadic Alzheimer's disease (sAD) is a progressive neurodegenerative disorder with
dysfunctional insulin signaling and energy metabolism. Emerging evidence suggests …

α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease

P Yamini, RS Ray, S Yadav, J Dhaliwal… - Pharmacology …, 2022 - Elsevier
Central insulin resistance is considered as one of the pathological hallmarks of Alzheimer's
disease (AD), similar to formation of amyloid plaques and neurofibrillary tangles (NFT) …

Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers

S Tripathi, U Kumari… - Journal of Food …, 2020 - Wiley Online Library
Dementia linked with cognitive impairments is the most prominent indication of Alzheimer's
disease (AD). In the current investigation, we have examined the streptozotocin‐(STZ) …

Immunotherapies in Huntington's disease and α-Synucleinopathies

O Fatoba, Y Ohtake, T Itokazu, T Yamashita - Frontiers in Immunology, 2020 - frontiersin.org
Modulation of immune activation using immunotherapy has attracted considerable attention
for many years as a potential therapeutic intervention for several inflammation-associated …

Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy, and ventricular enlargement with intracerebroventricular streptozotocin …

A Roy, S Sharma, TC Nag, J Katyal, YK Gupta… - Neurotoxicity …, 2022 - Springer
Insulin-resistant brain state is proposed to be the early sign of Alzheimer's disease (AD),
which can be studied in the intracerebroventricular streptozotocin (ICV-STZ) rodent model …