More than mortar: glia as architects of nervous system development and disease
I Lago-Baldaia, VM Fernandes… - Frontiers in Cell and …, 2020 - frontiersin.org
Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …
Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism
Y Wang, H Hu, X Liu, X Guo - Frontiers in Pharmacology, 2023 - frontiersin.org
Alzheimer's Disease (AD) is a global chronic disease in adults with beta-amyloid (Aβ)
deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although …
deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although …
Andrographolide attenuates short-term spatial and recognition memory impairment and neuroinflammation induced by a streptozotocin rat model of Alzheimer's …
LC Souza, MK Andrade, EM Azevedo, DC Ramos… - Neurotoxicity …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder clinically manifested by a gradual
cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of …
cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of …
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions
Background Activation of brain insulin receptors modulates reward sensitivity, inhibitory
control and memory. Variations in the functioning of this mechanism likely associate with …
control and memory. Variations in the functioning of this mechanism likely associate with …
Metabolic hormones mediate cognition
Recent biochemical and behavioural evidence indicates that metabolic hormones not only
regulate energy intake and nutrient content, but also modulate plasticity and cognition in the …
regulate energy intake and nutrient content, but also modulate plasticity and cognition in the …
siRNA Mediated GSK3β Knockdown Targets Insulin Signaling Pathway and Rescues Alzheimer's Disease Pathology: Evidence from In Vitro and In Vivo Studies
Sporadic Alzheimer's disease (sAD) is a progressive neurodegenerative disorder with
dysfunctional insulin signaling and energy metabolism. Emerging evidence suggests …
dysfunctional insulin signaling and energy metabolism. Emerging evidence suggests …
α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease
Central insulin resistance is considered as one of the pathological hallmarks of Alzheimer's
disease (AD), similar to formation of amyloid plaques and neurofibrillary tangles (NFT) …
disease (AD), similar to formation of amyloid plaques and neurofibrillary tangles (NFT) …
Ameliorative effects of apple cider vinegar on neurological complications via regulation of oxidative stress markers
S Tripathi, U Kumari… - Journal of Food …, 2020 - Wiley Online Library
Dementia linked with cognitive impairments is the most prominent indication of Alzheimer's
disease (AD). In the current investigation, we have examined the streptozotocin‐(STZ) …
disease (AD). In the current investigation, we have examined the streptozotocin‐(STZ) …
Immunotherapies in Huntington's disease and α-Synucleinopathies
O Fatoba, Y Ohtake, T Itokazu, T Yamashita - Frontiers in Immunology, 2020 - frontiersin.org
Modulation of immune activation using immunotherapy has attracted considerable attention
for many years as a potential therapeutic intervention for several inflammation-associated …
for many years as a potential therapeutic intervention for several inflammation-associated …
Cognitive dysfunction and anxiety resulting from synaptic downscaling, hippocampal atrophy, and ventricular enlargement with intracerebroventricular streptozotocin …
Insulin-resistant brain state is proposed to be the early sign of Alzheimer's disease (AD),
which can be studied in the intracerebroventricular streptozotocin (ICV-STZ) rodent model …
which can be studied in the intracerebroventricular streptozotocin (ICV-STZ) rodent model …