The OncoArray Consortium: a network for understanding the genetic architecture of common cancers

CI Amos, J Dennis, Z Wang, J Byun… - … , biomarkers & prevention, 2017 - AACR
Background: Common cancers develop through a multistep process often including
inherited susceptibility. Collaboration among multiple institutions, and funding from multiple …

Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review

KA Phillips, DL Veenstra, E Oren, JK Lee, W Sadee - Jama, 2001 - jamanetwork.com
ContextAdverse drug reactions are a significant cause of morbidity and mortality. Although
many adverse drug reactions are considered nonpreventable, recent developments suggest …

[图书][B] The medicalization of society: On the transformation of human conditions into treatable disorders

P Conrad - 2007 - torrossa.com
Come si intuisce dal titolo, l'argomento del volume è la medicalizzazione della società,
mentre il sottotitolo contiene già la tesi:“sulla trasformazione delle condizioni umane in …

[图书][B] Modelle von Gesundheit und Krankheit

A Franke - 2012 - books.google.com
In Deutschland ist nach der Gesundheitsreform vor der Gesundheitsreform. Aber welche
Gesundheit wird da eigentlich reformiert? Was bedeuten die Begriffe'Gesundheit'und' …

Polygenic susceptibility to breast cancer and implications for prevention

PDP Pharoah, A Antoniou, M Bobrow, RL Zimmern… - Nature …, 2002 - nature.com
The knowledge of human genetic variation that will come from the human genome
sequence makes feasible a polygenic approach to disease prevention, in which it will be …

The genetics and genomics of cancer

A Balmain, J Gray, B Ponder - Nature genetics, 2003 - nature.com
The past decade has seen great strides in our understanding of the genetic basis of human
disease. Arguably, the most profound impact has been in the area of cancer genetics, where …

Cancer genetics

BAJ Ponder - Nature, 2001 - nature.com
Cancer genetics has for many years focused on mutational events that have their primary
effect within the cancer cell. Recently that focus has widened, with evidence of the …

Modifier genes in mice and humans

JH Nadeau - Nature Reviews Genetics, 2001 - nature.com
An emerging theme of studies with spontaneous, engineered and induced mutant mice is
that phenotypes often depend on genetic background, implying that genetic modifiers have …

Advanced sequencing technologies: methods and goals

J Shendure, RD Mitra, C Varma, GM Church - Nature Reviews Genetics, 2004 - nature.com
Nearly three decades have passed since the invention of electrophoretic methods for DNA
sequencing. The exponential growth in the cost-effectiveness of sequencing has been …

[HTML][HTML] Polygenes, risk prediction, and targeted prevention of breast cancer

PDP Pharoah, AC Antoniou, DF Easton… - New England Journal …, 2008 - Mass Medical Soc
Background New developments in the search for susceptibility alleles in complex disorders
provide support for the possibility of a polygenic approach to the prevention and treatment of …