Knowledge of the molecular events that occur during the early stages of cancer has
advanced rapidly. The initiation and development of cancer involves several molecular …

Abstract Pyrimidine antagonists, for example, 5-fluorouracil (5-FU), cytarabine (ara-C) and
gemcitabine (dFdC), are widely used in chemotherapy regimes for colorectal, breast, head …

Fluorouracil (5-FU), together with other drugs such as oxaliplatin, is one of the most
important pharmacological agents in the treatment of colorectal cancer. Although mitogen …

Colorectal cancer has provided an excellent model for studying the genetic basis of cancer
and is one of the better‐understood malignancies in this regard. The orderly progression of …

Mutated forms of p53 are often expressed in a variety of human tumors. In addition to loss of
function of the p53 tumor suppressor, mutant p53s contribute to malignant process by …

Despite the introduction of several novel anticancer agents almost 50% of colorectal cancer
(CRC) patients die for cancer suggesting the necessity of new therapeutical approaches. In …

Both genetics and epigenetics regulate gene expression in cancer. Regulation by genetics
involves a change in the DNA sequence, whereas epigenetic regulation involves alteration …

To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the
microsatellite instability (MSI) by the amplification of 10 microsatellite loci and …

Abnormalities in the tumor suppressor gene p53 have been identified in over 60% of human
cancers. Since it plays such a pivotal role in cell growth regulation and apoptosis, the status …

Simple Summary Fluoropyrimidines represent the backbone of many combination
chemotherapy regimens for the treatment of solid cancers but are still associated with toxicity …