The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …
The NLRP3 inflammasome: Mechanism of action, role in disease and therapies
L Wang, AV Hauenstein - Molecular aspects of medicine, 2020 - Elsevier
NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …
Inflammasomes in neuroinflammatory and neurodegenerative diseases
S Voet, S Srinivasan, M Lamkanfi… - EMBO molecular …, 2019 - embopress.org
Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …
Pharmacological inhibitors of the NLRP3 inflammasome
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …
which deal with a plethora of pathogenic products and cellular products associated with …
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
L Vande Walle, M Lamkanfi - Nature Reviews Drug Discovery, 2024 - nature.com
Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …
world. As central instigators of the inflammatory response to infection and tissue damage …
Pharmacological inhibition of the NLRP3 inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction
Q Ma - Pharmacological reviews, 2023 - ASPET
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
Inflammasome assembly in neurodegenerative diseases
J Singh, ML Habean, N Panicker - Trends in Neurosciences, 2023 - cell.com
Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …
selectively vulnerable neuronal populations, often associated with the accumulation of …
[HTML][HTML] An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance
It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …
extent aging-associated conditions can be reversed. How the interface of immunity and …