Biospecific Chemistry for Covalent Linking of Biomacromolecules
Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …
processes. However, recent advancements in biospecific chemistry have enabled the …
Evolution of Pyrrolysyl-tRNA Synthetase: From Methanogenesis to Genetic Code Expansion
Over 20 years ago, the pyrrolysine encoding translation system was discovered in specific
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …
archaea. Our Review provides an overview of how the once obscure pyrrolysyl-tRNA …
Genetically encoded chemical crosslinking of carbohydrate
Protein–carbohydrate interactions play important roles in various biological processes, such
as organism development, cancer metastasis, pathogen infection and immune response, but …
as organism development, cancer metastasis, pathogen infection and immune response, but …
Bioorthogonal photocatalytic decaging-enabled mitochondrial proteomics
Z Huang, Z Liu, X Xie, R Zeng, Z Chen… - Journal of the …, 2021 - ACS Publications
Spatiotemporally resolved dissection of subcellular proteome is crucial to our understanding
of cellular functions in health and disease. We herein report a bioorthogonal and …
of cellular functions in health and disease. We herein report a bioorthogonal and …
Ultrafast bioorthogonal spin-labeling and distance measurements in mammalian cells using small, genetically encoded tetrazine amino acids
Site-directed spin-labeling (SDSL)─ in combination with double electron–electron
resonance (DEER) spectroscopy─ has emerged as a powerful technique for determining …
resonance (DEER) spectroscopy─ has emerged as a powerful technique for determining …
Constructing Photoactivatable Protein with Genetically Encoded Photocaged Glutamic Acid
X Yang, L Zhao, Y Wang, Y Ji, XC Su… - Angewandte …, 2023 - Wiley Online Library
Genetically replacing an essential residue with the corresponding photocaged analogues
via genetic code expansion (GCE) constitutes a useful and unique strategy to directly and …
via genetic code expansion (GCE) constitutes a useful and unique strategy to directly and …
Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs
As natural proteins generally do not bind targets in a covalent mode, the therapeutic
potential of covalent protein drugs remains largely unexplored. Recently, latent bioreactive …
potential of covalent protein drugs remains largely unexplored. Recently, latent bioreactive …
Advancing protein therapeutics through proximity-induced chemistry
Recent years have seen a remarkable growth in the field of protein-based medical
treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low …
treatments. Nevertheless, concerns have arisen regarding the cytotoxicity limitations, low …
Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo
controlled structural transformations and generate diverse macroscopic phenomenon under …
controlled structural transformations and generate diverse macroscopic phenomenon under …
Genetically encoded crosslinkers to address protein–protein interactions
Noncanonical amino acids (ncAAs) for photo‐and chemical crosslinking are powerful
biochemical tools for studying and manipulating interactions between proteins both in vitro …
biochemical tools for studying and manipulating interactions between proteins both in vitro …