Mechanisms and clinical uses of capsaicin
SK Sharma, AS Vij, M Sharma - European journal of pharmacology, 2013 - Elsevier
Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …
Transient receptor potential cation channels in disease
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
A Szallasi, DN Cortright, CA Blum, SR Eid - Nature reviews Drug …, 2007 - nature.com
The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
known as VR1) antagonists is based on the concept that endogenous agonists acting on …
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
[HTML][HTML] The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system
Q Du, Q Liao, C Chen, X Yang, R Xie, J Xu - Frontiers in Physiology, 2019 - frontiersin.org
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …
Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure
HJ Wang, W Wang, KG Cornish, GJ Rozanski… - …, 2014 - Am Heart Assoc
The enhanced cardiac sympathetic afferent reflex (CSAR) contributes to the exaggerated
sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively …
sympathoexcitation in chronic heart failure (CHF). Increased sympathoexcitation is positively …
Evidence for novel cannabinoid receptors
Cannabinoids, including the bioactive constituents of the marijuana plant, their synthetic
analogs, and endogenous lipids with cannabinoid-like activity, produce their biological …
analogs, and endogenous lipids with cannabinoid-like activity, produce their biological …
TRP channels: a journey towards a molecular understanding of pain
T Rosenbaum, SL Morales-Lázaro… - Nature Reviews …, 2022 - nature.com
The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …
role in the survival of organisms. Because pain is linked to a negative sensation, animals …
The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology
The cloning of the vanilloid receptor 1 opened a floodgate for discoveries regarding the
function of this complex molecule. It has been found that, in addition to heat, protons and …
function of this complex molecule. It has been found that, in addition to heat, protons and …
Development, maturation, and transdifferentiation of cardiac sympathetic nerves
K Kimura, M Ieda, K Fukuda - Circulation research, 2012 - Am Heart Assoc
The heart is electrically and mechanically controlled as a syncytium by the autonomic
nervous system. The cardiac nervous system comprises the sympathetic, parasympathetic …
nervous system. The cardiac nervous system comprises the sympathetic, parasympathetic …