Gaussian accelerated molecular dynamics: Principles and applications
Gaussian accelerated molecular dynamics (GaMD) is a robust computational method for
simultaneous unconstrained enhanced sampling and free energy calculations of …
simultaneous unconstrained enhanced sampling and free energy calculations of …
L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut
B Nüse, T Holland, M Rauh, RG Gerlach, J Mattner - Gut Microbes, 2023 - Taylor & Francis
ABSTRACT L-arginine (L-arg) is a versatile amino acid and a central intestinal metabolite in
mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple …
mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple …
Synthetic glycobiology: parts, systems, and applications
Protein glycosylation, the attachment of sugars to amino acid side chains, can endow
proteins with a wide variety of properties of great interest to the engineering biology …
proteins with a wide variety of properties of great interest to the engineering biology …
Speaking the host language: how Salmonella effector proteins manipulate the host
TD Pillay, SU Hettiarachchi, J Gan… - …, 2023 - microbiologyresearch.org
Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …
Arginine kinase activates Arginine for phosphorylation by pyramidalization and polarization
Arginine phosphorylation plays numerous roles throughout biology. Arginine kinase (AK)
catalyzes the delivery of an anionic phosphoryl group (PO3–) from ATP to a planar, trigonal …
catalyzes the delivery of an anionic phosphoryl group (PO3–) from ATP to a planar, trigonal …
Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways*[S]
JPM Newson, NE Scott, IYW Chung, TWF Lung… - Molecular & Cellular …, 2019 - ASBMB
Strains of Salmonella utilize two distinct type three secretion systems to deliver effector
proteins directly into host cells. The Salmonella effectors SseK1 and SseK3 are arginine …
proteins directly into host cells. The Salmonella effectors SseK1 and SseK3 are arginine …
Opportunities and challenges of bacterial glycosylation for the development of novel antibacterial strategies
L Yakovlieva, JA Fülleborn, MTC Walvoort - Frontiers in Microbiology, 2021 - frontiersin.org
Glycosylation is a ubiquitous process that is universally conserved in nature. The various
products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a …
products of glycosylation, such as polysaccharides, glycoproteins, and glycolipids, perform a …
Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector
Enteropathogenic E. coli NleB and related type III effectors catalyze arginine GlcNAcylation
of death domain (DD) proteins to block host defense, but the underlying mechanism is …
of death domain (DD) proteins to block host defense, but the underlying mechanism is …
New discoveries in bacterial N-glycosylation to expand the synthetic biology toolbox
H Nothaft, CM Szymanski - Current Opinion in Chemical Biology, 2019 - Elsevier
Historically, protein glycosylation was believed to be restricted to eukaryotes, but now is
abundantly represented in all three domains of life. The first bacterial N-linked glycosylation …
abundantly represented in all three domains of life. The first bacterial N-linked glycosylation …
An intra-bacterial activity for a T3SS effector
Many Gram-negative bacterial pathogens interact with mammalian cells by using type III
secretion systems (T3SS) to inject virulence proteins into host cells. A subset of these …
secretion systems (T3SS) to inject virulence proteins into host cells. A subset of these …