Communication pathways to and from the inner ear and their contributions to drug delivery
AN Salt, K Hirose - Hearing research, 2018 - Elsevier
The environment of the inner ear is highly regulated in a manner that some solutes are
permitted to enter while others are excluded or transported out. Drug therapies targeting the …
permitted to enter while others are excluded or transported out. Drug therapies targeting the …
[HTML][HTML] Anatomical basis of drug delivery to the inner ear
The isolated anatomical position and blood-labyrinth barrier hampers systemic drug delivery
to the mammalian inner ear. Intratympanic placement of drugs and permeation via the round …
to the mammalian inner ear. Intratympanic placement of drugs and permeation via the round …
Bioinspired multiresonant acoustic devices based on electrospun piezoelectric polymeric nanofibers
Cochlear hair cells are critical for the conversion of acoustic into electrical signals and their
dysfunction is a primary cause of acquired hearing impairments, which worsen with aging …
dysfunction is a primary cause of acquired hearing impairments, which worsen with aging …
Micro‐CT versus synchrotron radiation phase contrast imaging of human cochlea
High‐resolution images of the cochlea are used to develop atlases to extract anatomical
features from low‐resolution clinical computed tomography (CT) images. We compare …
features from low‐resolution clinical computed tomography (CT) images. We compare …
Models of cochlea used in Cochlear implant research: a review
F Hrncirik, I Roberts, I Sevgili, C Swords… - Annals of Biomedical …, 2023 - Springer
As the first clinically translated machine-neural interface, cochlear implants (CI) have
demonstrated much success in providing hearing to those with severe to profound hearing …
demonstrated much success in providing hearing to those with severe to profound hearing …
[HTML][HTML] A comparison of systemic and local dexamethasone administration: from perilymph/cochlea concentration to cochlear distribution
Y Wang, L Han, T Diao, Y Jing, L Wang, H Zheng… - Hearing Research, 2018 - Elsevier
Different types of inner ear diseases can damage different cochlear subsites by different
mechanisms. Steroids administered by different methods are commonly used for treating …
mechanisms. Steroids administered by different methods are commonly used for treating …
Immunohistochemical techniques for the human inner ear
IA Lopez, G Ishiyama, S Hosokawa… - Histochemistry and cell …, 2016 - Springer
In this review, we provide a description of the recent methods used for immunohistochemical
staining of the human inner ear using formalin-fixed frozen, paraffin and celloidin-embedded …
staining of the human inner ear using formalin-fixed frozen, paraffin and celloidin-embedded …
Microanatomy of the human tunnel of Corti structures and cochlear partition‐tonotopic variations and transcellular signaling
D Giese, H Li, W Liu, K Staxäng, M Hodik… - Journal of …, 2024 - Wiley Online Library
Auditory sensitivity and frequency resolution depend on the optimal transfer of sound‐
induced vibrations from the basilar membrane (BM) to the inner hair cells (IHCs), the …
induced vibrations from the basilar membrane (BM) to the inner hair cells (IHCs), the …
Visualizing collagen fibrils in the cochlea's tectorial and basilar membranes using a fluorescently labeled collagen-binding protein fragment
R de Sousa Lobo Ferreira Querido, X Ji… - Journal of the …, 2023 - Springer
Purpose A probe that binds to unfixed collagen fibrils was used to image the shapes and
fibrous properties of the TM and BM. The probe (CNA35) is derived from the bacterial …
fibrous properties of the TM and BM. The probe (CNA35) is derived from the bacterial …
Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti
AC Abbott, IE García, F Villanelo… - Frontiers in Cell and …, 2023 - frontiersin.org
Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness,
where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis …
where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis …