Communication pathways to and from the inner ear and their contributions to drug delivery

AN Salt, K Hirose - Hearing research, 2018 - Elsevier
The environment of the inner ear is highly regulated in a manner that some solutes are
permitted to enter while others are excluded or transported out. Drug therapies targeting the …

[HTML][HTML] Anatomical basis of drug delivery to the inner ear

R Glueckert, LJ Chacko, H Rask-Andersen, W Liu… - Hearing research, 2018 - Elsevier
The isolated anatomical position and blood-labyrinth barrier hampers systemic drug delivery
to the mammalian inner ear. Intratympanic placement of drugs and permeation via the round …

Bioinspired multiresonant acoustic devices based on electrospun piezoelectric polymeric nanofibers

G Viola, J Chang, T Maltby, F Steckler… - … applied materials & …, 2020 - ACS Publications
Cochlear hair cells are critical for the conversion of acoustic into electrical signals and their
dysfunction is a primary cause of acquired hearing impairments, which worsen with aging …

Micro‐CT versus synchrotron radiation phase contrast imaging of human cochlea

M Elfarnawany, SR Alam, SA Rohani… - Journal of …, 2017 - Wiley Online Library
High‐resolution images of the cochlea are used to develop atlases to extract anatomical
features from low‐resolution clinical computed tomography (CT) images. We compare …

Models of cochlea used in Cochlear implant research: a review

F Hrncirik, I Roberts, I Sevgili, C Swords… - Annals of Biomedical …, 2023 - Springer
As the first clinically translated machine-neural interface, cochlear implants (CI) have
demonstrated much success in providing hearing to those with severe to profound hearing …

[HTML][HTML] A comparison of systemic and local dexamethasone administration: from perilymph/cochlea concentration to cochlear distribution

Y Wang, L Han, T Diao, Y Jing, L Wang, H Zheng… - Hearing Research, 2018 - Elsevier
Different types of inner ear diseases can damage different cochlear subsites by different
mechanisms. Steroids administered by different methods are commonly used for treating …

Immunohistochemical techniques for the human inner ear

IA Lopez, G Ishiyama, S Hosokawa… - Histochemistry and cell …, 2016 - Springer
In this review, we provide a description of the recent methods used for immunohistochemical
staining of the human inner ear using formalin-fixed frozen, paraffin and celloidin-embedded …

Microanatomy of the human tunnel of Corti structures and cochlear partition‐tonotopic variations and transcellular signaling

D Giese, H Li, W Liu, K Staxäng, M Hodik… - Journal of …, 2024 - Wiley Online Library
Auditory sensitivity and frequency resolution depend on the optimal transfer of sound‐
induced vibrations from the basilar membrane (BM) to the inner hair cells (IHCs), the …

Visualizing collagen fibrils in the cochlea's tectorial and basilar membranes using a fluorescently labeled collagen-binding protein fragment

R de Sousa Lobo Ferreira Querido, X Ji… - Journal of the …, 2023 - Springer
Purpose A probe that binds to unfixed collagen fibrils was used to image the shapes and
fibrous properties of the TM and BM. The probe (CNA35) is derived from the bacterial …

Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti

AC Abbott, IE García, F Villanelo… - Frontiers in Cell and …, 2023 - frontiersin.org
Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness,
where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis …