Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis,
and signal transmission essential for neurons due to their high energy consumption …

The successful introduction of innovative treatment strategies into clinical practise strongly
depends on the availability of effective experimental models and their reliable pre-clinical …

Upon trauma, the adult murine peripheral nervous system (PNS) displays a remarkable
degree of spontaneous anatomical and functional regeneration. To explore extrinsic …

Abstract Background Local injection of BaCl 2 is an established model of acute injury to
study the regeneration of skeletal muscle. However, the mechanism by which BaCl 2 causes …

The failure of axons to regenerate in the damaged mammalian CNS is the main impediment
to functional recovery. There are many molecules and structures in the environment of the …

During development, half of brain white matter axons are maintained for growth, while the
remainder undergo developmental axon degeneration. After traumatic brain injury (TBI) …

Growth and destruction are central components of the neuronal injury response. Injured
axons that are capable of repair, including axons in the mammalian peripheral nervous …

Targeted muscle reinnervation (TMR) is a surgical procedure used to transfer residual
peripheral nerves from amputated limbs to targeted muscles, which allows the target …

Traumatic brain injury (TBI) triggers multiple pathobiological responses with differing onsets,
magnitudes, and durations. Identifying the therapeutic window of individual pathologies is …

Axons share a close relationship with Schwann cells, their glial partners in peripheral
nerves. An intricate axo‐glia network of signals and bioactive molecules regulates the major …