The functional roles of the circRNA/Wnt axis in cancer

C Xue, G Li, Q Zheng, X Gu, Z Bao, J Lu, L Li - Molecular Cancer, 2022 - Springer
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

The crosstalk between reactive oxygen species and noncoding RNAs: From cancer code to drug role

J Zuo, Z Zhang, M Li, Y Yang, B Zheng, P Wang… - Molecular Cancer, 2022 - Springer
Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen
species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven …

CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS

J Yi, L Wang, G Hu, Y Zhang, J Du, J Ding, X Ji… - The EMBO …, 2023 - embopress.org
The molecular mechanisms underlying estrogen receptor (ER)‐positive breast
carcinogenesis and endocrine therapy resistance remain incompletely understood. Here …

Estrogen‐Induced LncRNA, LINC02568, Promotes Estrogen Receptor‐Positive Breast Cancer Development and Drug Resistance Through Both In Trans and In Cis …

X Chen, J Ding, G Hu, X Shu, Y Liu, J Du… - Advanced …, 2023 - Wiley Online Library
Endocrine therapy is the frontline treatment for estrogen receptor (ER) positive breast cancer
patients. However, the primary and acquired resistance to endocrine therapy drugs remain …

CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3

L Yang, Y Chen, N Liu, Y Lu, W Ma, Z Yang, W Gan… - Molecular Cancer, 2022 - Springer
Abstract Background Functions of CircMET (hsa_circ_0082002) which is a circular RNA and
derived from MET gene remain understood incompletely. In the present study, Xp11. 2 …

Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis

Z Wang, Y Li, J Yang, Y Liang, X Wang, N Zhang… - Cell Death & …, 2022 - nature.com
Numerous studies have shown that circRNAs are aberrantly expressed in various cancers
and play a significant role in tumor progression. However, the molecular mechanisms of …

Circular RNAs in cell cycle regulation: Mechanisms to clinical significance

W Xiao, J Li, J Hu, L Wang, JR Huang, G Sethi… - Cell …, 2021 - Wiley Online Library
Circular RNAs (circRNAs), a type of non‐coding RNA, are single‐stranded circularized
molecules characterized by high abundance, evolutionary conservation and cell …

[PDF][PDF] A tumor-suppressive molecular axis EP300/circRERE/miR-6837-3p/MAVS activates type I IFN pathway and antitumor immunity to suppress colorectal cancer

N Ding, AB You, H Yang, GS Hu, CP Lai, W Liu… - Clinical Cancer …, 2023 - AACR
Purpose: The oncogenic role of circular RNAs (circRNA) has been well studied in cancers
including colorectal cancer. However, tumor-suppressive circRNAs and the mechanism …

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

M Liang, W Yao, B Shi, X Zhu, R Cai, Z Yu, W Guo… - Cell Death & …, 2021 - nature.com
Increasing studies have found that circular RNAs (circRNAs) are aberrantly expressed and
play important roles in the occurrence and development of human cancers. However, the …

[HTML][HTML] Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland

Z Chen, Y Liang, QY Lu, M Nazar, Y Mao… - Ecotoxicology and …, 2021 - Elsevier
Cadmium is a common environmental heavy metal pollutant that can accumulate over long
periods of time and cause disease. Thus, analysis of the molecular mechanisms affected by …