The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

Polypyrimidine Tract Binding Protein (PTB) is an intensely studied RNA binding protein
involved in several post-transcriptional regulatory events of gene expression. Initially …

Here, we generated a genome-scale shRNA library targeting long intergenic noncoding
RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function study in mouse …

LncRNAs have critical roles in various biological processes ranging from embryonic
development to human diseases, including cancer progression, although their detailed …

Establishment, maintenance, and exit from pluripotency require precise coordination of a
cell's molecular machinery. Substantial headway has been made in deciphering many …

Collectively, the ribosomopathies are caused by defects in ribosome biogenesis. Although
these disorders encompass deficiencies in a ubiquitous and fundamental process, the …

Invasion and migration is the hallmark of malignant tumors as well as the major cause for
breast cancer death. The polypyrimidine tract binding, PTB, protein serves as an important …

Polypyrimidine tract–binding protein (PTBP1) is an RNA-binding protein with various
molecular functions related to RNA metabolism and a major repressive regulator of …

Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common
features of most cancer types. CDKs have been shown to play important roles in tumor cell …

Polypyrimidine tract-binding protein 1 (PTBP1) involving in almost all steps of mRNA
regulation including alternative splicing metabolism during tumorigenesis due to its RNA …