Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

Microtubule-associated protein tau is essential for microtubule assembly and stabilization.
Hyperphosphorylation of the microtubule-associated protein tau plays an important …

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …

Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Human prion diseases are remarkable for long incubation times followed typically by rapid
clinical decline. Seed amplification assays and neurodegeneration biofluid biomarkers are …

The most prevalent genetic risk factor for Alzheimer's disease (AD) is Apolipoprotein E
(ApoE), a gene located on chromosome 19 that encodes three alleles (e2, e3, and e4) that …

It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …