The catalysis by primary and secondary amines of electrophilic substitution reactions in the
R-position of carbonyl compounds and related reactions via enamine intermediates is called …

Asymmetric multicomponent reactions involve the preparation of chiral compounds by the
reaction of three or more reagents added simultaneously. This kind of addition and reaction …

Spirooxindoles have become a privileged skeleton given their broad and promising
activities in various therapeutic areas. The strategies and catalyst systems described here …

Abstract The legacy of Gilbert Newton Lewis (1875–1946) pervades the lexicon of chemical
bonding and reactivity. The power of his concept of donor–acceptor bonding is evident in the …

The current status of organic synthesis is hampered by costly protecting‐group strategies
and lengthy purification procedures after each synthetic step. To circumvent these problems …

Enamines and imines have long been recognized as key intermediates in enzyme catalysis,
particularly within a class of enzymes organic chemists would very much like to emulate, the …

A novel organocatalytic asymmetric [3+ 2] cycloaddition reaction between
methyleneindolinones and allylic compounds yielding complex spirocyclopentaneoxindoles …

The utilisation of chiral secondary amines as promoters for asymmetric cascade reactions
has been subject of intensive research in asymmetric organocatalysis in the past few years …

Reactions in which several components are combined in sequence, and without isolation of
intermediates, are greatly sought because of the inherent molecular diversity, efficiency, and …

Der derzeitige Stand der organischen Synthese macht oft kostspielige
Schutzgruppenstrategien und aufwändige Reinigungsschritte nach jeder Synthesestufe …