Phage therapy: the pharmacology of antibacterial viruses

K Danis-Wlodarczyk, K Dąbrowska… - Current issues in …, 2021 - mdpi.com
Pharmacology can be differentiated into two key aspects, pharmacodynamics and
pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while …

Ecology and evolutionary biology of hindering phage therapy: The phage tolerance vs. phage resistance of bacterial biofilms

ST Abedon - Antibiotics, 2023 - mdpi.com
As with antibiotics, we can differentiate various acquired mechanisms of bacteria-mediated
inhibition of the action of bacterial viruses (phages or bacteriophages) into ones of tolerance …

Phage cocktail development for bacteriophage therapy: toward improving spectrum of activity breadth and depth

ST Abedon, KM Danis-Wlodarczyk, DJ Wozniak - Pharmaceuticals, 2021 - mdpi.com
Phage therapy is the use of bacterial viruses as antibacterial agents. A primary
consideration for commercial development of phages for phage therapy is the number of …

Microbial arsenal of antiviral defenses–part I

AB Isaev, OS Musharova, KV Severinov - Biochemistry (Moscow), 2021 - Springer
Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review
we will also consider viruses that infect Archaea). Constant threat of phage infection is a …

An optimized checkerboard method for phage-antibiotic synergy detection

I Nikolic, D Vukovic, D Gavric, J Cvetanovic… - Viruses, 2022 - mdpi.com
Phage-antibiotic synergy is a promising therapeutic strategy, but there is no reliable method
for synergism estimation. Although the time-kill curve assay is a gold standard, the method is …

Overcoming challenges to make bacteriophage therapy standard clinical treatment practice for cystic fibrosis

RN Ng, AS Tai, BJ Chang, SM Stick… - Frontiers in Microbiology, 2021 - frontiersin.org
Individuals with cystic fibrosis (CF) are given antimicrobials as prophylaxis against bacterial
lung infection, which contributes to the growing emergence of multidrug resistant (MDR) …

Phage-phage, phage-bacteria, and phage-environment communication

ST Abedon - Biocommunication of phages, 2020 - Springer
Besides obtaining and utilizing resources, organisms have three basic ecological tasks: to
survive, to reproduce, and to move. Survival is necessary for reproduction, reproduction …

Optimizing Protein Production in Therapeutic Phages against a Bacterial Pathogen, Mycobacterium abscessus

X Xia - Drugs and Drug Candidates, 2023 - mdpi.com
Therapeutic phages against pathogenic bacteria should kill the bacteria efficiently before the
latter evolve resistance against the phages. While many factors contribute to phage …

Antibacterial Potential of Non-Tailed Icosahedral Phages Alone and in Combination with Antibiotics

D Vukovic, S Gostimirovic, J Cvetanovic, D Gavric… - Current …, 2024 - Springer
Non-tailed icosahedral phages belonging to families Fiersviridae (phages MS2 and Qbeta),
Tectiviridae (PRD1) and Microviridae (phiX174) have not been considered in detail so far as …

[HTML][HTML] THE IMPACTS OF PHAGE-ACTINOBACTERIAL INTERACTIONS ON THE ECOLOGICAL FUNCTIONS OF ACTINOBACTERIA

NL Nwokolo, MC Enebe, CB Chigor, W Pathom-aree… - The Microbe, 2024 - Elsevier
A century ago, the knowledge of phages' contributions in the ecology of Actinobacteria by
controlling its population through lysis was brought to light. Ever since then, scientists have …