Triple negative breast cancer and non-small cell lung cancer: Clinical challenges and nano-formulation approaches
Triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are amongst
the most aggressive forms of solid tumors. TNBC is highlighted by absence of genetic …
the most aggressive forms of solid tumors. TNBC is highlighted by absence of genetic …
Clinical epigenetics settings for cancer and cardiovascular diseases: real-life applications of network medicine at the bedside
Despite impressive efforts invested in epigenetic research in the last 50 years, clinical
applications are still lacking. Only a few university hospital centers currently use epigenetic …
applications are still lacking. Only a few university hospital centers currently use epigenetic …
Network-based modeling of herb combinations in traditional Chinese medicine
Traditional Chinese medicine (TCM) has been practiced for thousands of years for treating
human diseases. In comparison to modern medicine, one of the advantages of TCM is the …
human diseases. In comparison to modern medicine, one of the advantages of TCM is the …
DrugComb update: a more comprehensive drug sensitivity data repository and analysis portal
Combinatorial therapies that target multiple pathways have shown great promises for
treating complex diseases. DrugComb (https://drugcomb. org/) is a web-based portal for the …
treating complex diseases. DrugComb (https://drugcomb. org/) is a web-based portal for the …
Co‐delivery of precisely prescribed multi‐prodrug combination by an engineered nanocarrier enables efficient individualized cancer chemotherapy
Y Li, Y Jiang, Z Zheng, N Du, S Guan, W Guo… - Advanced …, 2022 - Wiley Online Library
The limited anticancer drug library and the frequent occurrence of drug resistance have
driven monotherapy‐based cancer therapy into a difficult situation. Considering the …
driven monotherapy‐based cancer therapy into a difficult situation. Considering the …
Anticancer drug synergy prediction in understudied tissues using transfer learning
Objective Drug combination screening has advantages in identifying cancer treatment
options with higher efficacy without degradation in terms of safety. A key challenge is that the …
options with higher efficacy without degradation in terms of safety. A key challenge is that the …
Charting the fragmented landscape of drug synergy
Even as the clinical impact of drug combinations continues to accelerate, no consensus on
how to quantify drug synergy has emerged. Rather, surveying the landscape of drug synergy …
how to quantify drug synergy has emerged. Rather, surveying the landscape of drug synergy …
Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
S Li, H Liu, Z Lin, Z Li, Y Chen, B Chen, L Huang, X Lin… - Phytomedicine, 2022 - Elsevier
Background Chemotherapy drugs especially anthracyclines are widely used in the treatment
of hematological malignancies and solid tumors. However, their clinical application is limited …
of hematological malignancies and solid tumors. However, their clinical application is limited …
[HTML][HTML] Nanomaterial-assisted CRISPR gene-engineering–A hallmark for triple-negative breast cancer therapeutics advancement
Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …
[HTML][HTML] Prospect for application of mathematical models in combination cancer treatments
The long-term efficacy of targeted therapeutics for cancer treatment can be significantly
limited by the type of therapy and development of drug resistance, inter alia. Experimental …
limited by the type of therapy and development of drug resistance, inter alia. Experimental …