Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition,
poor health services and unavailability of prophylactic control measures, neglected …

Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Examining host–pathogen interactions in animals can capture aspects of infection that are
obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire …

Leishmaniasis is a neglected protozoan disease affecting over 12 million people globally
with no approved vaccines for human use. New World cutaneous leishmaniasis (CL) caused …

Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

Cyclic nucleotide binding domains (CNB) confer allosteric regulation by cAMP or cGMP to
many signaling proteins, including PKA and PKG. PKA of phylogenetically distant …

CRISPR/Cas9 gene editing has revolutionised loss-of-function experiments in Leishmania,
the causative agent of leishmaniasis. As Leishmania lack a functional non-homologous DNA …

Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …

Over 20 years after the approval of the first-in-class protein kinase inhibitor imatinib, the
biological function of a significant fraction of the human kinome remains poorly understood …

A key factor in the successful infection of a mammalian host by Leishmania parasites is their
conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss …