Melanosomes are unique organelles in melanocytes that produce melanin, the pigment for
skin, hair, and eye color. Tyrosinase is the essential and rate-limiting enzyme for melanin …

Actin is the structural protein of microfilaments, and it usually exists in two forms: monomer
and polymer. Among them, monomer actin is a spherical molecule composed of a …

The mechanical phenotype of the cell is critical for survival following deformations due to
confinement and fluid flow. One idea is that cancer cells are plastic and adopt different …

Continuous cell lines are important and commonly used in vitro models in breast cancer
(BC) research. Selection of the appropriate model cell line is crucial and requires …

We aim to understand, from acquired genetic alterations in tumors, why African American
(AA) men are more likely to develop aggressive prostate cancer. By analyzing somatic …

Extranodal NK/T-cell lymphoma, nasal type (ENKTL), is an aggressive malignancy with a
poor prognosis. While the introduction of L-asparaginase in the treatment of this disease has …

Inferring gene regulatory networks (GRNs) from single-cell RNA-seq (scRNA-seq) data is an
important computational question to find regulatory mechanisms involved in fundamental …

Background Ionizing radiation (IR) is one of the major clinical therapies of cancer, although it
increases the epithelial-mesenchymal transition (EMT) of non-small cell lung cancer …

Antibodies are employed ubiquitously in biomedical sciences, including for diagnostics and
therapeutics. One of the most important uses is for immunohistochemical (IHC) staining, a …

Retinopathy of prematurity (ROP) is a disorder of the developing retina of preterm infants.
ROP can lead to blindness because of abnormal angiogenesis that is the result of …