The utilization of PARP inhibitors (PARPis) has significantly improved the prognosis for
ovarian cancer patients. However, as the use of PARPis increases, the issue of PARPi …

Background & Aims The RNA-binding motif protein 39 (RBM39) functions as both an RNA-
binding protein and a splicing factor in a variety of cancer types. However, the function of …

RNA-binding proteins (RBPs) act as crucial regulators of gene expression within cells,
exerting precise control over processes such as RNA splicing, transport, localization …

Osteosarcoma is one of the most common malignant primary bone tumors and lacks
effective therapeutic targets. Recent studies have reported that RNA binding proteins (RBPs) …

Abstract E7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA
splicing by degrading the splicing factor RBM39 via ternary complex formation with the E3 …

Background Despite the use of targeted therapeutic approaches, T-cell acute lymphoblastic
leukemia (T-ALL) is still associated with a high incidence of complications and a poor …

RBM39: A druggable metabolic sensor linking RNA splicing, transcriptional regulation, and
metabolic reprogramming in cancer: Molecular Cell Skip to Main Content Advertisement …

Abstract Apo-transferrin (apo-TRF) is a vital protein for maintaining iron balance in the body,
which is produced by the liver. Indisulam (IDM) has been extensively used to treat cancer in …

Synthetic sulfonamide anticancer drugs, including E7820, indisulam, tasisulam, and
chloroquinoxaline sulfonamide, exhibit diverse mechanisms of action and therapeutic …

Background RNA-binding motif protein 39 (RBM39) is a well-known RNA-binding protein
involved in tumorigenesis; however, its role in hepatocellular carcinoma (HCC) remains …