Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally
proposed to correct for the blurring effect of atmospheric turbulence on images in ground …

Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

The extracellular space (ECS) of the brain has an extremely complex spatial organization,
which has defied conventional light microscopy. Consequently, despite a marked interest in …

In this Primer, we focus on the most recent advancements in stimulated emission depletion
(STED) microscopy, encompassing optics, computational microscopy and probes design …

Optical microscopy is widely used to visualize fine structures. When applied to bioimaging,
its performance is often degraded by sample-induced aberrations. In recent years, adaptive …

Rewiring neural circuits by the formation and elimination of synapses is thought to be a key
cellular mechanism of learning and memory in the mammalian brain. Dendritic spines are …

Specimen-induced aberration has been a major factor limiting the imaging depth of single-
molecule localization microscopy (SMLM). Here, we report the application of label-free …

Computational optical imaging is an emerging research field to realize specific imaging
functions and characteristics by jointly optimizing optical systems and signal processing. It is …

The extracellular space occupies approximately one-fifth of brain volume, molding a spider
web of gaps filled with interstitial fluid and extracellular matrix where neurons and glial cells …

Abstract Structured Illumination Microscopy enables live imaging with sub-diffraction
resolution. Unfortunately, optical aberrations can lead to loss of resolution and artifacts in …