The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the
regimen's individual ARV drugs and the number of HIV-1 mutations required for the …

Poor adherence to combined antiretroviral therapy (cART) has been shown to be a major
determinant of virologic failure, emergence of drug resistant virus, disease progression …

Abstract Background Ibalizumab, a humanized IgG4 monoclonal antibody, blocks the entry
of human immunodeficiency virus type 1 (HIV-1) by noncompetitive binding to CD4. Methods …

Three decades into the HIV/AIDS epidemic there is a growing cohort of perinatally HIV-
infected adolescents globally. Their survival into adolescence and beyond represent one of …

Abstract Background Minor (ie,< 20% prevalence) drug-resistant human immunodeficiency
virus (HIV) variants may go undetected, yet be clinically important Objectives To compare …

Antiretroviral-therapy rollout in resource-poor countries is often associated with limited, if
any, HIV-RNA monitoring. The effect of variable monitoring on the emergence of resistance …

Background Retaining participants in cohort studies with multiple follow-up waves is difficult.
Commonly, researchers are faced with the problem of missing data, which may introduce …

Objective: To characterize the temporal changes in mortality and life expectancy among HIV-
positive individuals initiating antiretroviral therapy in British Columbia, Canada, from 1993 to …

This paper describes the synthesis of several 1-benzyl-1H-1, 2, 3-triazoles attached to
different carbohydrate templates and their in vitro inhibitory profile against HIV-1 reverse …

Background: The emergence of viral resistance is one of the greatest challenges in the
treatment of HIV infection. Maraviroc is the first member of a new class of antiretroviral …