Given the global burden of psychotic disorders, the identification of patients with early-onset
psychosis (EOP; that is, onset before the age of 18) at higher risk of adverse outcome should …

Successful treatment of first-episode psychosis is one of the major factors that impacts long-
term prognosis. Currently, there are no satisfactory biological markers (biomarkers) to …

Background Early-onset psychosis (EOP) refers to the development of a first episode of
psychosis before 18 years of age. Individuals at clinical high risk for psychosis (CHR-P) …

Neurocognitive impairment is a well-established feature of first-episode psychosis (FEP).
Neurotoxicity hypothesis of psychosis suggests that untreated psychosis before the initiation …

Aim Early intervention in psychosis (EIP) is a well‐established approach with the intention of
early detection and treatment of psychotic disorders. Its clinical and economic benefits are …

Schizophrenia is associated with diverse changes in the brain's transcriptome and
proteome. Underlying these changes is the complex dysregulation of gene expression and …

Objective: Schizophrenia spectrum and other psychotic disorders often have their onset in
adolescence. The sequelae of these illnesses can negatively alter the trajectory of …

The cognitive problems experienced by people with schizophrenia not only impede recovery
but also interfere with treatments designed to improve overall functioning. Hence there has …

La esquizofrenia es un síndrome clínicamente heterogéneo que afecta a múltiples
dimensiones vitales del individuo. Su tratamiento requiere un abordaje multidimensional en …

Background Cognitive impairment is a core feature of schizophrenia with unclear
mechanisms, particularly neurocognition. The objective of this study was to investigate the …