In patients with cardiovascular disease (CVD), depression is common, persistent, and
associated with worse health‐related quality of life, recurrent cardiac events, and mortality …

Epidemiological studies have demonstrated a close relationship between depression and
cardiovascular disease (CVD). Although it is known that the central nervous system (CNS) …

Background: Mechanical stress on the heart, such as high blood pressure, initiates
inflammation and causes hypertrophic heart disease. However, the regulatory mechanism of …

Background: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase
receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic …

Heart failure is a complex clinical syndrome characterized by insufficient cardiac function. In
addition to abnormalities intrinsic to the heart, dysfunction of other organs and dysregulation …

Background Brain‐derived neurotrophic factor (BDNF) is a pleiotropic peptide involved in
maintaining endothelial integrity. It is unknown if circulating BDNF levels are associated with …

Neurotrophins (NTs) were first identified as target-derived survival factors for neurons of the
central and peripheral nervous system (PNS). They are known to control neural cell fate …

Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An
enriched environment (EE) is involved in the regulation of macrophage-related activities and …

BDNF and its associated tropomyosin-related kinase receptor B (TrkB) nurture vessels and
nerves serving the heart. However, the direct effect of BDNF/TrkB signaling on the …

The actions of BDNF (Brain-derived Neurotrophic Factor) in regulating neuronal
development and modulating synaptic activity have been extensively studied and well …