Currently, around 11 million people are living with a tumour that contains an inactivating
mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53.
Recent studies have shown that Mdm2 is activated in response to a variety of oncogenic …

In 1969, a remarkable cancer predisposition syndrome was reported by Li and Fraumeni.
Using a classical epidemiologic approach, they retrospectively evaluated 280 medical …

The importance of the p53 stress response pathway in the suppression of tumor formation is
well documented. In a previous report, a single nucleotide polymorphism (SNP309 T/G) was …

The p53 pathway is perturbed in the majority of human cancers. Although this most
frequently occurs through the direct mutation or deletion of p53 itself, there are a number of …

Large scale distributed systems like Grids are difficult to study only from theoretical models
and simulators. Most Grids deployed at large scale are production platforms that are …

Abstract Glucose-regulated protein 78 (GRP78) has been implicated in the protection of
tumor cells from cytotoxic damage and apoptosis and thus assists cells in survival under …

The p53 tumor suppressor gene (TP53) is mutated more often in human cancers than any
other gene yet reported. Of importance, it is mutated frequently in the common human …

DNA copy number variations (CNVs) are a significant and ubiquitous source of inherited
human genetic variation. However, the importance of CNVs to cancer susceptibility and …