Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms
A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …
socioeconomic implications for patients and their care-givers. Recent advances in medical …
Microglia as hackers of the matrix: sculpting synapses and the extracellular space
JD Crapser, MA Arreola, KI Tsourmas… - Cellular & molecular …, 2021 - nature.com
Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …
Retinal microglia: just bystander or target for therapy?
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury
I Francos-Quijorna, M Sánchez-Petidier… - Nature …, 2022 - nature.com
Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …
neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical …
Microglial activation and its implications in the brain diseases
S Thameem Dheen, C Kaur… - Current medicinal …, 2007 - ingentaconnect.com
An inflammatory process in the central nervous system (CNS) is believed to play an
important role in the pathway leading to neuronal cell death in a number of …
important role in the pathway leading to neuronal cell death in a number of …
The bright side of the glial scar in CNS repair
A Rolls, R Shechter, M Schwartz - Nature Reviews Neuroscience, 2009 - nature.com
Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …
Extracellular matrix regulation of inflammation in the healthy and injured spinal cord
AD Gaudet, PG Popovich - Experimental neurology, 2014 - Elsevier
Throughout the body, the extracellular matrix (ECM) provides structure and organization to
tissues and also helps regulate cell migration and intercellular communication. In the injured …
tissues and also helps regulate cell migration and intercellular communication. In the injured …
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury
H Lee, RJ McKeon… - Proceedings of the …, 2010 - National Acad Sciences
Chondroitin sulfate proteoglycans (CSPGs) are a major class of axon growth inhibitors that
are up-regulated after spinal cord injury (SCI) and contribute to regenerative failure …
are up-regulated after spinal cord injury (SCI) and contribute to regenerative failure …
Manipulating the glial scar: chondroitinase ABC as a therapy for spinal cord injury
EJ Bradbury, LM Carter - Brain research bulletin, 2011 - Elsevier
Chondroitin sulphate proteoglycans (CSPGs) are potent inhibitors of growth in the adult
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …
Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following …
Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …
we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via …