Ene‐Reductase‐Catalyzed Aromatization of Simple Cyclohexanones to Phenols
J Chen, S Qi, Z Wang, L Hu, J Liu, G Huang… - Angewandte …, 2024 - Wiley Online Library
Direct aromatization of cyclohexanones to synthesize substituted phenols represents a
significant challenge in modern synthetic chemistry. Herein, we describe a novel ene …
significant challenge in modern synthetic chemistry. Herein, we describe a novel ene …
Progress of 3-ketosteroid Δ1-dehydrogenases for steroid production
B Zhang, DF Zhou, MJ Li, JH Lan, H Li… - Systems Microbiology …, 2024 - Springer
ketosteroid Δ1-dehydrogenases (Δ1-KstDs) are FAD-dependent and substrate-inducing
enzymes, which catalyze the introduction of double bonds between C1 and C2 atoms of the …
enzymes, which catalyze the introduction of double bonds between C1 and C2 atoms of the …
Highly Efficient Enzymatic Synthesis of C6-Substituted Δ1-3-Ketosteroids Enabled by Finely Tuning the Substrate Binding of 3-Ketosteroid-Δ1-Dehydrogenase
Y Wang, R Zhang, X Chen, Z Yang, J Feng… - ACS Sustainable …, 2024 - ACS Publications
Enzymatic Δ1-dehydrogenation mediated by 3-ketosteroid-Δ1-dehydrogenases (Δ1-KstDs,
EC 1.3. 99.4) offers an attractive method to access pharmaceutically important Δ1-3 …
EC 1.3. 99.4) offers an attractive method to access pharmaceutically important Δ1-3 …
High‐efficiency bioconversion of phytosterol to bisnoralcohol by metabolically engineered Mycobacterium neoaurum in a micro‐emulsion system
X Wang, X Ke, H Dong, Z Liu, Y Zheng - Biotechnology Journal, 2024 - Wiley Online Library
Hydroxy‐20‐methylpregn‐4‐en‐3‐one (4‐HBC, bisnoralcohol) is a crucial intermediate for
the synthesis of steroidal drugs. Significant challenges including by‐products formation and …
the synthesis of steroidal drugs. Significant challenges including by‐products formation and …
Rational design of a cyclohexanone dehydrogenase for enhanced α, β-desaturation and substrate specificity
W Singh, NL Brown, HV McCue, SR Marriott… - Chemical …, 2024 - pubs.rsc.org
The selective α, β-desaturation of cyclic carbonyl compounds, which are found in the core of
many steroid and bioactive molecules, using green chemistry is highly desirable. To achieve …
many steroid and bioactive molecules, using green chemistry is highly desirable. To achieve …
Enzymatic synthesis of a skin active ingredient-glochidone by 3-ketosteroid dehydrogenase from Sterolibacterium denitrificans
AM Wojtkiewicz, G Oleksy, MA Malinowska… - The Journal of Steroid …, 2024 - Elsevier
In this study, we applied AcmB2, sourced from Sterolibacterium denitrificans, to catalyze the
oxidative dehydrogenation of 3-ketolupeol (lupenone), a derivative of lupeol, triterpene …
oxidative dehydrogenation of 3-ketolupeol (lupenone), a derivative of lupeol, triterpene …
1,2-Hydrogenation and Transhydrogenation Catalyzed by 3-Ketosteroid Δ1-Dehydrogenase from Sterolibacterium denitrificans—Kinetics, Isotope Labelling and QM …
AM Wojtkiewicz, M Glanowski, P Waligórski… - International Journal of …, 2022 - mdpi.com
Bacteria and fungi that are able to metabolize steroids express 3-ketosteroid-Δ1-
dehydrogenases (KstDs). KstDs such as AcmB form Sterolibacterium denitrificans Chol-1 …
dehydrogenases (KstDs). KstDs such as AcmB form Sterolibacterium denitrificans Chol-1 …