Therapeutic inhibition of CXCR1/2: where do we stand?
S Sitaru, A Budke, R Bertini, M Sperandio - Internal and Emergency …, 2023 - Springer
Mounting experimental evidence from in vitro and in vivo animal studies points to an
essential role of the CXCL8-CXCR1/2 axis in neutrophils in the pathophysiology of …
essential role of the CXCL8-CXCR1/2 axis in neutrophils in the pathophysiology of …
Chemokine signaling and the regulation of bidirectional leukocyte migration in interstitial tissues
Motile cells navigate through complex tissue environments that include both attractive and
repulsive cues. In response to tissue wounding, neutrophils, primary cells of the innate …
repulsive cues. In response to tissue wounding, neutrophils, primary cells of the innate …
[HTML][HTML] Designing efficient multi-epitope peptide-based vaccine by targeting the antioxidant thioredoxin of bancroftian filarial parasite
Thioredoxin is a low molecular weight redox-active protein of filarial parasite that plays a
crucial role in downregulating the host immune response to prolong the survival of the …
crucial role in downregulating the host immune response to prolong the survival of the …
Computer-aided discovery, design, and investigation of COVID-19 therapeutics
Abstract Coronavirus disease 2019 (COVID-19) pandemic is currently the most serious
public health threat faced by mankind. Thus, the severe acute respiratory syndrome …
public health threat faced by mankind. Thus, the severe acute respiratory syndrome …
Reverse vaccinology assisted design of a novel multi-epitope vaccine to target Wuchereria bancrofti cystatin: An immunoinformatics approach
Proteases are the critical mediators of immunomodulation exerted by the filarial parasites to
bypass and divert host immunity. Cystatin is a small (∼ 15 kDa) immunomodulatory filarial …
bypass and divert host immunity. Cystatin is a small (∼ 15 kDa) immunomodulatory filarial …
Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation
I Kufareva, BS Stephens, LG Holden… - Proceedings of the …, 2014 - National Acad Sciences
Chemokines and their receptors regulate cell migration during development, immune
system function, and in inflammatory diseases, making them important therapeutic targets …
system function, and in inflammatory diseases, making them important therapeutic targets …
A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics
CC Chang, CH Yang, CH Chuang, SJ Jiang… - Communications …, 2023 - nature.com
Abstract Human interleukin-10 (IL-10) is an immunosuppressive and anti-inflammatory
cytokine, and its expression is upregulated in tumor tissues and serum samples of patients …
cytokine, and its expression is upregulated in tumor tissues and serum samples of patients …
In-silico evidences on filarial cystatin as a putative ligand of human TLR4
Cystatin is a small molecular weight immunomodulatory protein of filarial parasite that plays
a pivotal role in downregulating the host immune response to prolong the survival of the …
a pivotal role in downregulating the host immune response to prolong the survival of the …
Internal water channel formation in CXCR4 is crucial for Gi-protein coupling upon activation by CXCL12
Chemokine receptor CXCR4 is a major drug target for numerous diseases because of its
involvement in the regulation of cell migration and the developmental process. In this study …
involvement in the regulation of cell migration and the developmental process. In this study …
Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1
The dynamic interactions between G protein-coupled receptors (GPCRs) and their cognate
protein partners are central to several cell signaling pathways. For example, the association …
protein partners are central to several cell signaling pathways. For example, the association …