[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

AL Onugwu, CS Nwagwu, OS Onugwu… - Journal of Controlled …, 2023 - Elsevier
Diseases affecting the anterior segment of the eye are the primary causes of vision
impairment and blindness globally. Drug administration through the topical ocular route is …

Functional supramolecular systems: Design and applications

IS Antipin, MV Alfimov, VV Arslanov… - Russian Chemical …, 2021 - iopscience.iop.org
The interest in functional supramolecular systems for the design of innovative materials and
technologies, able to fundamentally change the world, is growing at a high pace. The huge …

Penetration enhancers in ocular drug delivery

RV Moiseev, PWJ Morrison, F Steele… - Pharmaceutics, 2019 - mdpi.com
There are more than 100 recognized disorders of the eye. This makes the development of
advanced ocular formulations an important topic in pharmaceutical science. One of the ways …

Supramolecular biopharmaceutical carriers based on host–guest interactions

W Li, W Xu, S Zhang, J Li, J Zhou, D Tian… - Journal of Agricultural …, 2022 - ACS Publications
Traditional drugs have the disadvantages of poor permeability and low solubility, which
makes the utilization of pesticides lower and brings many side effects. With the continuous …

[HTML][HTML] Integrating stimuli-responsive properties in host-guest supramolecular drug delivery systems

AS Braegelman, MJ Webber - Theranostics, 2019 - ncbi.nlm.nih.gov
Host-guest motifs are likely the most recognizable manifestation of supramolecular
chemistry. These complexes are characterized by the organization of small molecules on the …

Review of approaches for increasing ophthalmic bioavailability for eye drop formulations

OL Lanier, MG Manfre, C Bailey, Z Liu, Z Sparks… - Aaps Pharmscitech, 2021 - Springer
Ophthalmic diseases represent a significant problem as over 2 billion people worldwide
suffer from vison impairment and blindness. Eye drops account for around 90% of …

The role of additives on the interaction behavior of levofloxacin hemihydrate with crown ether: UV–visible spectroscopic and DFT techniques

M Hossain, S Mahbub, MA Rub, S Rana… - Journal of Molecular …, 2023 - Elsevier
The levofloxacin hemihydrate (LH); a third generation floroquinolone antibiotic drug works
against bacteria by killing bacteria or stopping their growth. But it has some side effects …

Recent updates on supramolecular‐based drug delivery–macrocycles and supramolecular gels

VS Saji - The Chemical Record, 2022 - Wiley Online Library
Supramolecules‐based drug delivery has attracted significant recent research attention as it
could enhance drug solubility, retention time, targeting, and stimuli responsiveness. Among …

[HTML][HTML] Chitosan/β-glycerophosphate in situ forming thermo-sensitive hydrogel for improved ocular delivery of moxifloxacin hydrochloride

MH Asfour, SH Abd El-Alim, GEA Awad… - European Journal of …, 2021 - Elsevier
The aim of the current work is to develop a thermo-sensitive hydrogel system of moxifloxacin
hydrochloride (MOX) for improved ocular delivery. Fifteen formulations were prepared at …

Small Molecule Inhibitors Targeting the “Undruggable” Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective

Q Cui, C Huang, JY Liu, JT Zhang - Journal of Medicinal …, 2023 - ACS Publications
Survivin, a homodimeric protein and a member of the IAP family, plays a vital function in cell
survival and cycle progression by interacting with various proteins and complexes. Its …