Mechanisms of Toxoplasma gondii persistence and latency

WJ Sullivan Jr, V Jeffers - FEMS microbiology reviews, 2012 - academic.oup.com
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …

Population Structure of Toxoplasma gondii: Clonal Expansion Driven by Infrequent Recombination and Selective Sweeps

LD Sibley, JW Ajioka - Annu. Rev. Microbiol., 2008 - annualreviews.org
Toxoplasma gondii is among the most successful parasites. It is capable of infecting all
warm-blooded animals and causing opportunistic disease in humans. T. gondii has a …

Gr1+ inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii

IR Dunay, RA DaMatta, B Fux, R Presti, S Greco… - Immunity, 2008 - cell.com
The enteric pathogen Toxoplasma gondii is controlled by a vigorous innate T helper 1 (Th1)
cell response in the murine model. We demonstrated that after oral infection, the parasite …

Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens

Z Zhao, B Fux, M Goodwin, IR Dunay, D Strong… - Cell host & …, 2008 - cell.com
The physiologic importance of autophagy proteins for control of mammalian bacterial and
parasitic infection in vivo is unknown. Using mice with granulocyte-and macrophage-specific …

Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii

JI MacRae, L Sheiner, A Nahid, C Tonkin, B Striepen… - Cell host & …, 2012 - cell.com
Toxoplasma gondii proliferates within host cell vacuoles where the parasite relies on host
carbon and nutrients for replication. To assess how T. gondii utilizes these resources, we …

Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe

RE Gilbert, K Freeman, EG Lago… - PLoS Neglected …, 2008 - journals.plos.org
Background Toxoplasmic retinochoroiditis appears to be more severe in Brazil, where it is a
leading cause of blindness, than in Europe, but direct comparisons are lacking. Evidence is …

Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome

A Khan, B Fux, C Su, JP Dubey… - Proceedings of the …, 2007 - National Acad Sciences
Toxoplasma gondii is a highly prevalent protozoan parasite that infects a wide range of
animals and threatens human health by contaminating food and water. A markedly limited …

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii

K Nagamune, LM Hicks, B Fux, F Brossier, EN Chini… - Nature, 2008 - nature.com
Calcium controls a number of critical events, including motility, secretion, cell invasion and
egress by apicomplexan parasites. Compared to animal and plant cells, the molecular …

Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1–PDL-1 blockade

R Bhadra, JP Gigley, LM Weiss… - Proceedings of the …, 2011 - National Acad Sciences
In this study, we document that Toxoplasma gondii differentiation and reactivation are
mediated by systemic CD8 T-cell dysfunction during chronic infection. We demonstrate that …

Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous system

JM Brooks, GL Carrillo, J Su, DS Lindsay, MA Fox… - MBio, 2015 - Am Soc Microbiol
During infections with the protozoan parasite Toxoplasma gondii, gamma-aminobutyric acid
(GABA) is utilized as a carbon source for parasite metabolism and also to facilitate parasite …