Mechanisms of Toxoplasma gondii persistence and latency
WJ Sullivan Jr, V Jeffers - FEMS microbiology reviews, 2012 - academic.oup.com
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …
disease, particularly in immunocompromised individuals. Central to its transmission and …
Population Structure of Toxoplasma gondii: Clonal Expansion Driven by Infrequent Recombination and Selective Sweeps
LD Sibley, JW Ajioka - Annu. Rev. Microbiol., 2008 - annualreviews.org
Toxoplasma gondii is among the most successful parasites. It is capable of infecting all
warm-blooded animals and causing opportunistic disease in humans. T. gondii has a …
warm-blooded animals and causing opportunistic disease in humans. T. gondii has a …
Gr1+ inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii
The enteric pathogen Toxoplasma gondii is controlled by a vigorous innate T helper 1 (Th1)
cell response in the murine model. We demonstrated that after oral infection, the parasite …
cell response in the murine model. We demonstrated that after oral infection, the parasite …
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
The physiologic importance of autophagy proteins for control of mammalian bacterial and
parasitic infection in vivo is unknown. Using mice with granulocyte-and macrophage-specific …
parasitic infection in vivo is unknown. Using mice with granulocyte-and macrophage-specific …
Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii
Toxoplasma gondii proliferates within host cell vacuoles where the parasite relies on host
carbon and nutrients for replication. To assess how T. gondii utilizes these resources, we …
carbon and nutrients for replication. To assess how T. gondii utilizes these resources, we …
Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe
RE Gilbert, K Freeman, EG Lago… - PLoS Neglected …, 2008 - journals.plos.org
Background Toxoplasmic retinochoroiditis appears to be more severe in Brazil, where it is a
leading cause of blindness, than in Europe, but direct comparisons are lacking. Evidence is …
leading cause of blindness, than in Europe, but direct comparisons are lacking. Evidence is …
Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome
Toxoplasma gondii is a highly prevalent protozoan parasite that infects a wide range of
animals and threatens human health by contaminating food and water. A markedly limited …
animals and threatens human health by contaminating food and water. A markedly limited …
Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii
Calcium controls a number of critical events, including motility, secretion, cell invasion and
egress by apicomplexan parasites. Compared to animal and plant cells, the molecular …
egress by apicomplexan parasites. Compared to animal and plant cells, the molecular …
Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1–PDL-1 blockade
R Bhadra, JP Gigley, LM Weiss… - Proceedings of the …, 2011 - National Acad Sciences
In this study, we document that Toxoplasma gondii differentiation and reactivation are
mediated by systemic CD8 T-cell dysfunction during chronic infection. We demonstrate that …
mediated by systemic CD8 T-cell dysfunction during chronic infection. We demonstrate that …
Toxoplasma gondii infections alter GABAergic synapses and signaling in the central nervous system
During infections with the protozoan parasite Toxoplasma gondii, gamma-aminobutyric acid
(GABA) is utilized as a carbon source for parasite metabolism and also to facilitate parasite …
(GABA) is utilized as a carbon source for parasite metabolism and also to facilitate parasite …