The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

K Mima, T Hamada, K Inamura, H Baba, T Ugai… - Gut …, 2023 - Taylor & Francis
Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Who is in the driver's seat? Parvimonas micra: An understudied pathobiont at the crossroads of dysbiotic disease and cancer

DL Higashi, MC Krieger, H Qin, Z Zou… - Environmental …, 2023 - Wiley Online Library
Recent advances in our understanding of microbiome composition at sites of inflammatory
dysbiosis have triggered a substantial interest in a variety of historically understudied …

The role of oral microbiota in cancer

Z Lan, WJ Liu, H Cui, KL Zou, H Chen… - Frontiers in …, 2023 - frontiersin.org
Cancer remains a significant global challenge, with an estimated 47% increase in cancer
patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor …

Not All Carcinogens Are Directly Mutagenic: A Holistic View of the Environmental Exposure–Cancer Connection

D Okwan-Duodu, AR Pandiri… - Annual Review of Cancer …, 2024 - annualreviews.org
Cancers, a leading cause of morbidity and mortality worldwide, are undergoing notable
shifts in incidence patterns. Cancer subtypes generally associated with advancing age are …

The value of intratumoral microbiota in the diagnosis and prognosis of tumors

L Zhou, W Zhang, S Fan, D Wang… - Cell Biochemistry and …, 2024 - Wiley Online Library
Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate in
tumor development by affecting tumor cells directly and the tumor microenvironment (TME) …

Application of Mendelian randomization to assess host gene–gut microbiota correlations in patients with esophageal cancer

Z Zhang, G Zhang, Z Huang, Y Shi… - Frontiers in Microbiology, 2023 - frontiersin.org
Background Increasing evidence suggests that esophageal cancer (ESCA) may be
correlated with gut flora. However, their causal connection remains unclear. This study …

Non-invasive early detection on esophageal squamous cell carcinoma and precancerous lesions by microbial biomarkers combining epidemiological factors in China

M Li, D Shao, Z Fan, J Qin, J Xu, Q Huang, X Li… - Journal of …, 2024 - Springer
Background Microbiota may be associated with esophageal squamous cell carcinoma
(ESCC) development. However, it is not known the predictive value of microbial biomarkers …

Altered salivary microbiota profile in patients with abdominal aortic aneurysm

WZ Lin, BY Chen, P Qiu, LJ Zhou, YL Li, LJ Du, Y Liu… - Heliyon, 2023 - cell.com
Evidence suggests that the DNA of oral pathogens is detectable in the dilated aortic tissue of
abdominal aortic aneurysm (AAA), one of the most fatal cardiovascular diseases. However …

Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity

P Wang, Y Liu, L Wei, J Wang, J Wang… - Cancer Investigation, 2024 - Taylor & Francis
Esophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%,
underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific …

肿瘤内微生物组的研究进展

李欣然, 梁依依, 屠红 - 中国癌症杂志, 2023 - china-oncology.com
肿瘤内微生物组是指存在于肿瘤中并构成肿瘤微环境的微生物群体. 虽然肿瘤病毒的研究已有百
余年历史, 但细菌, 真菌等其他微生物在肿瘤中的存在现象及生物学意义却一直未有定论 …