[HTML][HTML] The potential of genomics for infectious disease forecasting
Genomic technologies have led to tremendous gains in understanding how pathogens
function, evolve and interact. Pathogen diversity is now measurable at high precision and …
function, evolve and interact. Pathogen diversity is now measurable at high precision and …
[HTML][HTML] Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic …
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …
numerous biotechnological applications. The NP discovery process is expensive and time …
Evolutionary-scale prediction of atomic-level protein structure with a language model
Recent advances in machine learning have leveraged evolutionary information in multiple
sequence alignments to predict protein structure. We demonstrate direct inference of full …
sequence alignments to predict protein structure. We demonstrate direct inference of full …
IMG/VR v4: an expanded database of uncultivated virus genomes within a framework of extensive functional, taxonomic, and ecological metadata
AP Camargo, S Nayfach, IMA Chen… - Nucleic acids …, 2023 - academic.oup.com
Viruses are widely recognized as critical members of all microbiomes. Metagenomics
enables large-scale exploration of the global virosphere, progressively revealing the …
enables large-scale exploration of the global virosphere, progressively revealing the …
The IMG/M data management and analysis system v. 7: content updates and new features
IMA Chen, K Chu, K Palaniappan, A Ratner… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Integrated Microbial Genomes & Microbiomes system (IMG/M: https://img. jgi.
doe. gov/m/) at the Department of Energy (DOE) Joint Genome Institute (JGI) continues to …
doe. gov/m/) at the Department of Energy (DOE) Joint Genome Institute (JGI) continues to …
[HTML][HTML] Assessment of global health risk of antibiotic resistance genes
Z Zhang, Q Zhang, T Wang, N Xu, T Lu, W Hong… - Nature …, 2022 - nature.com
Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in
the last decade. Many genes can confer resistance, but evaluating the relative health risks of …
the last decade. Many genes can confer resistance, but evaluating the relative health risks of …
[HTML][HTML] Expansion of the global RNA virome reveals diverse clades of bacteriophages
High-throughput RNA sequencing offers broad opportunities to explore the Earth RNA
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …
virome. Mining 5,150 diverse metatranscriptomes uncovered> 2.5 million RNA virus contigs …
[HTML][HTML] Unraveling the functional dark matter through global metagenomics
Metagenomes encode an enormous diversity of proteins, reflecting a multiplicity of functions
and activities,. Exploration of this vast sequence space has been limited to a comparative …
and activities,. Exploration of this vast sequence space has been limited to a comparative …
Twenty-five years of Genomes OnLine Database (GOLD): data updates and new features in v. 9
S Mukherjee, D Stamatis, CT Li… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Genomes OnLine Database (GOLD)(https://gold. jgi. doe. gov/) at the
Department of Energy Joint Genome Institute (DOE-JGI) continues to maintain its role as one …
Department of Energy Joint Genome Institute (DOE-JGI) continues to maintain its role as one …
[HTML][HTML] Petabase-scale sequence alignment catalyses viral discovery
Public databases contain a planetary collection of nucleic acid sequences, but their
systematic exploration has been inhibited by a lack of efficient methods for searching this …
systematic exploration has been inhibited by a lack of efficient methods for searching this …