[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
Long non-coding RNAs in the doxorubicin resistance of cancer cells
S Ashrafizaveh, M Ashrafizadeh, A Zarrabi… - Cancer Letters, 2021 - Elsevier
Chemotherapy is the main treatment used for cancer patients failing surgery. Doxorubicin
(DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in …
(DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in …
NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …
Pathogenesis and current treatment strategies of hepatocellular carcinoma
D Tümen, P Heumann, K Gülow, CN Demirci… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …
five-year survival rates leading to a substantial worldwide burden for healthcare systems …
Fisetin and quercetin: promising flavonoids with chemopreventive potential
Despite advancements in healthcare facilities for diagnosis and treatment, cancer remains
the leading cause of death worldwide. As prevention is always better than cure, efficient …
the leading cause of death worldwide. As prevention is always better than cure, efficient …
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
M Ashrafizadeh, H Saebfar, MH Gholami… - Expert opinion on …, 2022 - Taylor & Francis
Introduction The application of doxorubicin (DOX) in cancer therapy has been limited due to
its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the …
its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the …
Piceatannol: A natural stilbene for the prevention and treatment of cancer
Abstract The World Health Organization (WHO) has documented that cancer is the second
foremost reason for death worldwide. Various factors are responsible for cancer, for …
foremost reason for death worldwide. Various factors are responsible for cancer, for …
Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …
ROS are typically produced under physiological conditions and play crucial roles in living …
Antioxidant role of kaempferol in prevention of hepatocellular carcinoma
N Sharma, S Biswas, N Al-Dayan, AS Alhegaili… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are noxious to cells because their increased level interacts
with the body's defense mechanism. These species also cause mutations and uncontrolled …
with the body's defense mechanism. These species also cause mutations and uncontrolled …
Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …