[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Long non-coding RNAs in the doxorubicin resistance of cancer cells

S Ashrafizaveh, M Ashrafizadeh, A Zarrabi… - Cancer Letters, 2021 - Elsevier
Chemotherapy is the main treatment used for cancer patients failing surgery. Doxorubicin
(DOX) is a well-known chemotherapeutic agent capable of suppressing proliferation in …

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

Pathogenesis and current treatment strategies of hepatocellular carcinoma

D Tümen, P Heumann, K Gülow, CN Demirci… - Biomedicines, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

Fisetin and quercetin: promising flavonoids with chemopreventive potential

D Kashyap, VK Garg, HS Tuli, MB Yerer, K Sak… - Biomolecules, 2019 - mdpi.com
Despite advancements in healthcare facilities for diagnosis and treatment, cancer remains
the leading cause of death worldwide. As prevention is always better than cure, efficient …

Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance

M Ashrafizadeh, H Saebfar, MH Gholami… - Expert opinion on …, 2022 - Taylor & Francis
Introduction The application of doxorubicin (DOX) in cancer therapy has been limited due to
its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the …

Piceatannol: A natural stilbene for the prevention and treatment of cancer

K Banik, AM Ranaware, C Harsha, T Nitesh… - Pharmacological …, 2020 - Elsevier
Abstract The World Health Organization (WHO) has documented that cancer is the second
foremost reason for death worldwide. Various factors are responsible for cancer, for …

Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

HS Tuli, J Kaur, K Vashishth, K Sak, U Sharma… - Archives of …, 2023 - Springer
ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …

Antioxidant role of kaempferol in prevention of hepatocellular carcinoma

N Sharma, S Biswas, N Al-Dayan, AS Alhegaili… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are noxious to cells because their increased level interacts
with the body's defense mechanism. These species also cause mutations and uncontrolled …

Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery

S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki… - Antioxidants, 2021 - mdpi.com
Doxorubicin (DOX) is extensively applied in cancer therapy due to its efficacy in suppressing
cancer progression and inducing apoptosis. After its discovery, this chemotherapeutic agent …