Raman imaging of small biomolecules

Y Shen, F Hu, W Min - Annual review of biophysics, 2019 - annualreviews.org
Imaging techniques greatly facilitate the comprehensive knowledge of biological systems.
Although imaging methodology for biomacromolecules such as protein and nucleic acids …

Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease

GA Pantelopulos, CB Abraham… - Annual Review of …, 2024 - annualreviews.org
Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Three-dimensional operando optical imaging of particle and electrolyte heterogeneities inside Li-ion batteries

R Pandya, L Valzania, F Dorchies, F Xia… - Nature …, 2023 - nature.com
Understanding (de) lithiation heterogeneities in battery materials is key to ensure optimal
electrochemical performance. However, this remains challenging due to the three …

Single‐Molecule 3D Orientation Imaging Reveals Nanoscale Compositional Heterogeneity in Lipid Membranes

J Lu, H Mazidi, T Ding, O Zhang… - Angewandte Chemie …, 2020 - Wiley Online Library
In soft matter, thermal energy causes molecules to continuously translate and rotate, even in
crowded environments, thereby impacting the spatial organization and function of most …

Fast compressive Raman bio-imaging via matrix completion

F Soldevila, J Dong, E Tajahuerce, S Gigan… - Optica, 2019 - opg.optica.org
Raman microscopy is a powerful method combining non-invasiveness with no special
sample preparation. Because of this remarkable simplicity, it has been widely exploited in …

[HTML][HTML] Dynamic pattern generation in cell membranes: Current insights into membrane organization

K Raghunathan, AK Kenworthy - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
It has been two decades since the lipid raft hypothesis was first presented. Even today,
whether these nanoscale cholesterol-rich domains are present in cell membranes is not …

Quantitative label-free imaging of lipid domains in single bilayers by hyperspectral coherent Raman scattering

A Nahmad-Rohen, D Regan, F Masia… - Analytical …, 2020 - ACS Publications
Lipid phase separation in cellular membranes is thought to play an important role in many
biological functions. This has prompted the development of synthetic membranes to study …

Regimes of complex lipid bilayer phases induced by cholesterol concentration in MD simulation

GA Pantelopulos, JE Straub - Biophysical journal, 2018 - cell.com
Cholesterol is essential to the formation of phase-separated lipid domains in membranes.
Lipid domains can exist in different thermodynamic phases depending on the molecular …

Raman spectra of deuterated hydrocarbons for labeling applications

KA Okotrub, DV Shamaeva… - Journal of Raman …, 2022 - Wiley Online Library
Raman spectroscopy is used for studying the composition of cell lipidome. However, the
Raman approach suffers from limited distinguish power for different lipids. In recent years …

Evaluating pathological levels of intracellular cholesterol through Raman and surface-enhanced Raman spectroscopies

E Baria, C Dallari, F Mattii, FS Pavone, C Credi… - Scientific Reports, 2024 - nature.com
Versatile methods for the quantification of intracellular cholesterol are essential for
understanding cellular physiology and for diagnosing disorders linked to cholesterol …