[HTML][HTML] Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

The changing landscape of atherosclerosis

P Libby - Nature, 2021 - nature.com
Emerging evidence has spurred a considerable evolution of concepts relating to
atherosclerosis, and has called into question many previous notions. Here I review this …

Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics

L He, CL Zhang, Q Chen, L Wang, Y Huang - Pharmacology & therapeutics, 2022 - Elsevier
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

[HTML][HTML] More than just a monolayer: the multifaceted role of endothelial cells in the pathophysiology of atherosclerosis

M Mussbacher, K Schossleitner… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …

Transcytosis-enabled active extravasation of tumor nanomedicine

Q Zhou, J Li, J Xiang, S Shao, Z Zhou, J Tang… - Advanced Drug Delivery …, 2022 - Elsevier
Extravasation is the first step for nanomedicines in circulation to reach targeted solid tumors.
Traditional nanomedicines have been designed to extravasate into tumor interstitium …

ROS responsive nanoparticles loaded with lipid-specific AIEgen for atherosclerosis-targeted diagnosis and bifunctional therapy

H Xu, P She, B Ma, Z Zhao, G Li, Y Wang - Biomaterials, 2022 - Elsevier
Atherosclerosis, which is triggered by endothelial damage, progressive local inflammation
and excessive lipid accumulation, is one of the most common cardiovascular diseases in …

[HTML][HTML] Deacetylation of Caveolin-1 by Sirt6 induces autophagy and retards high glucose-stimulated LDL transcytosis and atherosclerosis formation

Y Zhao, X Jia, X Yang, X Bai, Y Lu, L Zhu, W Cheng… - Metabolism, 2022 - Elsevier
Background Atherosclerosis (AS) is the basis of diabetic macrovascular complications. The
plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) …

[HTML][HTML] Autophagy, pyroptosis, and ferroptosis: new regulatory mechanisms for atherosclerosis

L Lin, MX Zhang, L Zhang, D Zhang, C Li… - Frontiers in cell and …, 2022 - frontiersin.org
Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …

Cav-1 (Caveolin-1) deficiency increases autophagy in the endothelium and attenuates vascular inflammation and atherosclerosis

X Zhang, CM Ramírez, B Aryal… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Endothelial Cav-1 (caveolin-1) expression plays a relevant role during
atherogenesis by controlling NO production, vascular inflammation, LDL (low-density …

Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation

MA Del Pozo, FN Lolo, A Echarri - Current opinion in cell biology, 2021 - Elsevier
Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …