Lamellarins and related pyrrole-derived alkaloids from marine organisms

H Fan, J Peng, MT Hamann, JF Hu - Chemical reviews, 2008 - ACS Publications
Marine organisms have proven to be rich sources of unique alkaloids. In earlier surveys we
comprehensively reviewed several intriguing groups of marine alkaloids, including the …

Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions

F Bellina, R Rossi - Tetrahedron, 2006 - Elsevier
Five-membered heterocycle derivatives with two aryl groups on adjacent positions include
several classes of natural and unnatural compounds that exhibit a variety of biological and …

Selective Palladium‐Catalyzed Suzuki–Miyaura Reactions of Polyhalogenated Heteroarenes

R Rossi, F Bellina, M Lessi - Advanced Synthesis & Catalysis, 2012 - Wiley Online Library
Abstract The palladium‐catalyzed Suzuki–Miyaura reaction of multiply halogenated,
electron‐rich and electron‐deficient heteroarenes is one of the most reliable and …

A modular synthesis of the lamellarins: total synthesis of lamellarin G trimethyl ether

ST Handy, Y Zhang, H Bregman - The Journal of Organic …, 2004 - ACS Publications
A modular synthesis of the lamellarin family of natural products has been developed that is
based on the application of three iterative halogenation/cross-coupling reaction sequences …

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and …

BL Deng, MD Cullen, Z Zhou, TL Hartman… - Bioorganic & medicinal …, 2006 - Elsevier
The HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) constitute a large and
structurally diverse set of compounds, several of which are currently used in the treatment of …

Pyrrole protection

B Jolicoeur, EE Chapman, A Thompson, WD Lubell - Tetrahedron, 2006 - Elsevier
The synthetic chemistry of the pyrrolic unit is dominated by electrophilic aromatic substitution
and pyrrole is much more reactive than benzene in this respect, as a result of the lone pair at …

Synthesis and evaluation of the antiproliferative activity of novel pyrrolo [1, 2-a] quinoxaline derivatives, potential inhibitors of Akt kinase. Part II

V Desplat, S Moreau, A Gay, SB Fabre… - Journal of Enzyme …, 2010 - Taylor & Francis
Attenuation of protein kinases by selective inhibitors is an extremely active field of activity in
anticancer drug development. Therefore, Akt, a serine/threonine protein kinase, also known …

Palladium‐Catalysed Cross‐Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry

GP McGlacken, IJS Fairlamb - European Journal of Organic …, 2009 - Wiley Online Library
Palladium‐catalysed cross‐coupling reactions are routinely used in the synthesis of
important organic and organometallic compounds, including advanced materials and …

A practical palladium catalyzed dehalogenation of aryl halides and α-haloketones

J Chen, Y Zhang, L Yang, X Zhang, J Liu, L Li, H Zhang - Tetrahedron, 2007 - Elsevier
A practical and high-yielding protocol for the dehalogenation of aromatic halides is
presented. In the presence of palladium acetate, triphenylphosphine, and potassium …

The suzuki–Miyaura cross-coupling reaction of halogenated aminopyrazoles: method development, scope, and mechanism of dehalogenation side reaction

L Jedinák, R Zátopková, H Zemánková… - The Journal of …, 2017 - ACS Publications
The efficient Suzuki–Miyaura cross-coupling reaction of halogenated aminopyrazoles and
their amides or ureas with a range of aryl, heteroaryl, and styryl boronic acids or esters has …