• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The microbiology, epidemiology, diagnostics, and treatment of infective endocarditis (IE)
have changed significantly since the Duke Criteria were published in 1994 and modified in …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Abstract Aims The EURO-ENDO registry aimed to study the management and outcomes of
patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 …

Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated
with high morbidity and mortality (> 70%), and presents numerous challenges during clinical …

The genus Enterococcus comprises a ubiquitous group of Gram-positive bacteria that are of
great relevance to human health for their role as major causative agents of health care …

Enterococci are unusually well adapted for survival and persistence in a variety of adverse
environments, including on inanimate surfaces in the hospital environment and at sites of …

Background Patients with infective endocarditis on the left side of the heart are typically
treated with intravenous antibiotic agents for up to 6 weeks. Whether a shift from intravenous …

The evolution of Staphylococcus aureus during the modern antibiotic era has been
delineated by distinct strain emergence events, many of which include acquisition of …