The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …

Chronic inflammation is a prerequisite for the development of cancers. Here, we present the
framework of a novel theory termed as Cancer Evolution-Development (Cancer Evo-Dev) …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …

Much remains unknown about the progression and heterogeneity of mutational processes in
different cancers and their diagnostic and clinical potential. A growing body of evidence …

The enzyme activation-induced cytidine deaminase (AID) initiates somatic hypermutation
(SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes, critical actions …

Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin
ligase RAD18 and its downstream effectors, the 'Y-family'Trans-Lesion Synthesis (TLS) DNA …

Cancer is a genetic disorder, meaning that a plethora of different mutations, whether somatic
or germ line, underlie the etiology of the 'Emperor of Maladies'. Point mutations …

ABSTRACT DNA polymerase (pol) η is a specialized error-prone polymerase with at least
two quite different and contrasting cellular roles: to mitigate the genetic consequences of …

Betel quid (BQ) chewing is a prevailing risk for oral squamous cell carcinoma (OSCC) in
Southeast Asia. Yet, the detailed mechanisms by which BQ chewing damages the genome …