Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Epithelial–mesenchymal transition (EMT) is a crucial embryonic programme that is executed
by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and …

The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …

Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

Metastasis is the major cause of cancer-related deaths; therefore, the prevention and
treatment of metastasis are fundamental to improving clinical outcomes. Epithelial …