Hypercholesterolemia and microvascular dysfunction: interventional strategies

PA Stapleton, AG Goodwill, ME James, RW Brock… - Journal of …, 2010 - Springer
Hypercholesterolemia is defined as excessively high plasma cholesterol levels, and is a
strong risk factor for many negative cardiovascular events. Total cholesterol levels above …

Dyslipidemias and microcirculation

T Padró, G Vilahur, L Badimon - Current Pharmaceutical …, 2018 - ingentaconnect.com
Dyslipidemia is widely accepted as one of the major risk factors in cardiovascular disease
mainly due to its contribution in the pathogenesis of atherosclerosis in medium-sized and …

Maternal cholesterol levels during gestation: boon or bane for the offspring?

VS Jayalekshmi, S Ramachandran - Molecular and cellular biochemistry, 2021 - Springer
An increase in cholesterol levels is perceived during pregnancy and is considered as a
normal adaptive response to the development of the fetus. In some pregnancies, excessive …

Chronic interval exercise training prevents BKCa channel-mediated coronary vascular dysfunction in aortic-banded miniswine

TD Olver, JC Edwards, BS Ferguson… - Journal of Applied …, 2018 - journals.physiology.org
Conventional treatments have failed to improve the prognosis of heart failure with preserved
ejection fraction (HFpEF) patients. Thus, the purpose of this study was to determine the …

Effect of high‐calcium diet on coronary artery disease in Ossabaw miniature swine with metabolic syndrome

AK Phillips‐Eakley, ML McKenney‐Drake… - Journal of the …, 2015 - Am Heart Assoc
Background Calcium is a shortfall essential nutrient that has been a mainstay of
osteoporosis management. Recent and limited findings have prompted concern about the …

[HTML][HTML] Different sensitivities of porcine coronary arteries and veins to BAY 60–2770, a soluble guanylate cyclase activator

M Tawa, K Nakagawa, M Ohkita - Journal of Pharmacological Sciences, 2025 - Elsevier
Nitric oxide (NO)-donor drugs, which stimulate reduced form of soluble guanylate cyclase
(sGC), have different efficacy to the arteries and veins. This study examined whether sGC …

Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF rat

AK Bunker, AA Arce-Esquivel… - American Journal …, 2010 - journals.physiology.org
We tested the hypothesis that physical activity can attenuate the temporal decline of ACh-
induced endothelium-dependent relaxation during type 2 diabetes mellitus progression in …

Changes in adrenoceptors and G-protein-coupled receptor kinase 2 in L-NAME-induced hypertension compared to spontaneous hypertension in rats

E Oliver, N Flacco, C Arce, MD Ivorra… - Journal of vascular …, 2014 - karger.com
This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor
kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance …

Maternal hypercholesterolemia in gestational diabetes and the association with placental endothelial dysfunction

A Leiva, CD de Medina… - Gestational Diabetes …, 2013 - books.google.com
Pregnancy is a physiological condition characterized by a progressive, weeks of
gestationdependent increase in maternal triglycerides (hypertriglyceridemia) and total …

Effects of chronic nitric oxide synthase inhibition on responses to acute exercise in swine

RM McAllister, SC Newcomer… - Journal of Applied …, 2008 - journals.physiology.org
Nitric oxide (NO) is potentially involved in several responses to acute exercise. We tested
the hypotheses that inhibition of NO formation reduces maximal O2 delivery to muscle, but …