G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Epidemiological studies with human populations indicate associations between maternal
infection during pregnancy and increased risk in offspring for central nervous system (CNS) …

Placing a patient in a state of general anesthesia is crucial for safely and humanely
performing most surgical and many nonsurgical procedures. How anesthetic drugs create …

These guidelines from the British Association for Psychopharmacology address the scope
and targets of pharmacological treatment for schizophrenia. A consensus meeting, involving …

The allostatic load (AL) model represents an interdisciplinary approach to comprehensively
conceptualize and quantify chronic stress in relation to pathologies throughout the life cycle …

Background: Antipsychotic-induced metabolic side effects are major concerns in
psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not …

Context Most of what we know about antipsychotic drug effects is at the receptor level, distal
from the neural system effects that mediate their clinical efficacy. Studying cerebral function …