Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

Background: Optimal treatment to prevent or delay cognitive decline, mild cognitive
impairment (MCI), or dementia is uncertain. Purpose: To summarize current evidence on the …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Patients with treatment-resistant depression (TRD) have higher rates of relapse and
pronounced decreases in daily functioning and health-related quality of life compared to …

Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Objective There is a long‐standing debate in the literature whether depressive symptoms
increase the risk of dementia in older with mild cognitive impairment (MCI). We aim to …

Key Clinical Points Depression in the Elderly Late-life depression (occurring in persons 60
years of age or older) is common and is often associated with coexisting medical illness …

As identified in previously published articles, including those published in this issue, the
detection of early cognitive impairment among older adult populations is worthy of …

Mood disorders are highly prevalent and are the leading cause of disability worldwide. The
neurobiological mechanisms underlying depression remain poorly understood, although …

Late-life depression is frequently associated with cognitive impairment. Depressive
symptoms are often associated with or even precede a dementia syndrome. Moreover …