Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

Currently regeneration of tooth and periodontal damage still remains great challenge. Stem
cell‐based tissue engineering raised novel therapeutic strategies for tooth and periodontal …

Intrauterine adhesion refers to endometrial repair disorders which are usually caused by
uterine injury and may lead to a series of complications such as abnormal menstrual …

The fabrication of 3D tissues retaining the original functions of tissues/organs in vitro is
crucial for optimal tissue engineering and regenerative medicine. The fabrication of 3D …

Bone marrow mesenchymal stem cells (BMSCs), which were first discovered in bone
marrow, are capable of differentiating into osteoblasts, chondrocytes, fat cells, and even …

The erasure of epigenetic modifications across the genome of somatic cells is an essential
requirement during their reprogramming into induced pluripotent stem cells (iPSCs). Vitamin …

DNA methylation plays an important role in the maintenance of genomic stability. Ten-
eleven translocation proteins (TETs) are a family of iron (Fe2+) and α-KG-dependent …

The teeth are vertebrate-specific, highly specialized organs performing fundamental
functions of mastication and speech, the maintenance of which is crucial for orofacial …

Background Researchers have been exploring the molecular mechanisms underlying the
control of periodontal ligament stem cell (PDLSC) osteogenic differentiation. Recently, long …