We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

The time course of the beneficial pharmacological effect of a drug has long been considered
to depend merely on the temporal fluctuation of its free concentration. Only in the last …

Abstract Background and Purpose Optimal drug therapy often requires continuing high
levels of target occupancy. Besides the traditional pharmacokinetic contribution, target …

Hesperidin and naringin are predominant flavonoids in citrus fruits and exert various
biological activities. However, mechanism of these activities has not been completely …

Losartan and honokiol are small molecules which have been described to inhibit
aggregation of platelets by collagen. Losartan has been proposed to block clustering of …

The angiotensin II (Ang II) type 1 and type 2 receptors (AT1R and AT2R) orchestrate an
array of biological processes that regulate human health. Aberrant function of these …

Ruscogenin, a kind of steroid saponin, has been shown to have significant anti-oxidant, anti-
inflammatory, and anti-thrombotic characteristics. Furthermore, it has the potential to be …

Introduction: Optimal drug therapy often requires continuing high levels of target occupancy.
Besides the traditional pharmacokinetic (PK) contribution thereto, drug–target interactions …

The drug: membrane interactions for the antihypertensive AT1 antagonist losartan, the
prototype of the sartans class, are studied herein using an integrated approach. The …

Renin–angiotensin aldosterone system inhibitors are for a long time extensively used for the
treatment of cardiovascular and renal diseases. AT1 receptor blockers (ARBs or sartans) act …