Blood-brain barrier disruption: a culprit of cognitive decline?

J Che, Y Sun, Y Deng, J Zhang - Fluids and Barriers of the CNS, 2024 - Springer
Cognitive decline covers a broad spectrum of disorders, not only resulting from brain
diseases but also from systemic diseases, which seriously influence the quality of life and …

Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications

SJ Doran, RP Sawyer - Frontiers in Neuroscience, 2024 - frontiersin.org
Alzheimer's disease (AD) affects over 6 million people over the age of 65. The advent of new
anti-amyloid monoclonal antibodies as treatment for early Alzheimer's disease these …

Immune system activation and cognitive impairment in arterial hypertension

S Schreiber, P Arndt, L Morton… - … of Physiology-Cell …, 2024 - journals.physiology.org
Chronic arterial hypertension disrupts the integrity of the cerebral microvasculature,
doubling the risk of age-related dementia. Despite sufficient antihypertensive therapy in still …

Pathophysiology of cerebral small vessel disease: a journey through recent discoveries

N Dupré, A Drieu, A Joutel - The Journal of clinical …, 2024 - Am Soc Clin Investig
Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related
small vessel pathologies that affect multiple regions. Disease manifestations range from …

Perivascular space dysfunction in cerebral small vessel disease is related to neuroinflammation

H Hong, D Tozer, Y Chen, R Brown, A Low, HS Markus - Brain, 2024 - academic.oup.com
Enlarged perivascular spaces are a feature of cerebral small vessel disease, and it has
been hypothesized that they may reflect impaired glymphatic drainage. The mechanisms …

[HTML][HTML] Assessing Mild Traumatic Brain Injury-Associated Blood–Brain Barrier (BBB) Damage and Restoration Using Late-Phase Perfusion Analysis by 3D ASL MRI …

CR Joseph - International Journal of Molecular Sciences, 2024 - mdpi.com
Mild traumatic brain injury (mTBI) is a common occurrence around the world, associated with
a variety of blunt force and torsion injuries affecting all age groups. Most never reach …

The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach

M van Dinther, PHM Voorter, E Zhang, SMJ van Kuijk… - GeroScience, 2024 - Springer
Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the
pathophysiology of cerebral small vessel disease (cSVD). Individually measurable functions …

Exploring the Neural Mechanisms of Mirrored‐Self Misidentification in Alzheimer's Disease

Z Sun, G Chen, J Gan, Y Tang, H Wu… - … Journal of Geriatric …, 2024 - Wiley Online Library
Objective Alzheimer's disease (AD) is a complex neurodegenerative condition that causes a
range of cognitive disturbances, including mirror‐self misidentification syndrome (MSM), in …

Linking peripheral atherosclerosis to blood–brain barrier disruption: elucidating its role as a manifestation of cerebral small vessel disease in vascular cognitive …

Á Nyúl-Tóth, R Patai, A Csiszar, A Ungvari, R Gulej… - GeroScience, 2024 - Springer
Aging plays a pivotal role in the pathogenesis of cerebral small vessel disease (CSVD),
contributing to the onset and progression of vascular cognitive impairment and dementia …

Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET

L Zhou, TD Nguyen, GC Chiang, XH Wang… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Mapping of microscopic changes in the perivascular space (PVS) of the
cerebral cortex, beyond magnetic resonance‐visible PVS in white matter, may enhance our …